New Silicon-Based Strategies for Organic Synthesis

有机合成新硅基策略

• 批准号: 0957276
• 负责人: Karl Scheidt
• 金额: $ 43万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957276&HistoricalAwards=false
• 关键词: New; Silicon; Based; Strategies; Organic

The principal goal of this research program is the discovery of new, unconventional reagents and their development as tools for chemical synthesis. This plan outlines a comprehensive approach to the development of new catalytic reactions using organosilicon compounds. Acylsilanes are silicon-containing small molecules that have been investigated for over 30 years due to their unusual reactivity (e.g., acyl anions), yet there remains many opportunities to exploit and utilize these unique compounds in chemical synthesis. Silyloxyallenes are versatile compounds with significant potential in cycloadditions, tandem bond-forming sequences and group transfer reactions. By integrating the reactivity of these unique enolsilanes with tandem or subsequent reactions, the PI will be able to access important compound classes with high efficiency and minimal waste. The complementary mechanistic and target-oriented approaches driving this work allows for studies that are unique among current investigations in organosilicon and catalysis research. The group is developing sophisticated and highly versatile methods for the convergent construction of new small molecules that have broad utility.Broader Impact: The investigation of the research goals of this proposal will simultaneously provide the undergraduate students, graduate students, postdoctoral fellows and visiting scholars working on these projects with essential experience and scientific knowledge. They will learn synthesis techniques, instrumentation analysis, organometallic chemistry, purification science, and problem solving strategies. In addition to acquiring laboratory skills, the Scheidt team has regular weekly full group meetings and daily sub-group gatherings to discuss prior results and chart new research directions. Weekly meetings include research presentations, short discussions on recent high-impact publications, and chemical problems for pedagogical growth. Overall, the individual training in the laboratory combined with small, medium and large group formats for presenting and discussing chemical topics provides for a rich, vibrant and dynamic learning environment. Additionally, there is strong participation by underrepresented groups in the laboratory which engenders a professional, dynamic and multi-ethnic work environment. Professor Scheidt will continue to organize and host the annual Chicago Organic Symposium as well as strengthen ties with institutions such as Western Michigan University and Chicago State University. This outreach component is centered on creating an interchange of ideas throughout the Department of Chemistry and between academic and industrial personnel from a variety of backgrounds and is expected to have a unique and significant impact on society.

该研究计划的主要目标是发现新的非常规试剂及其作为化学合成工具的发展。该计划概述了使用有机硅化合物开发新催化反应的综合方法。 酰基硅烷是含硅小分子，由于其不寻常的反应性（例如，酰基阴离子），但仍有许多机会在化学合成中开发和利用这些独特的化合物。 硅氧基丙二烯是一种用途广泛的化合物，在环加成、串联成键和基团转移反应中具有重要的应用潜力。通过将这些独特的烯醇硅烷的反应性与串联或后续反应相结合，PI将能够以高效率和最小的浪费获得重要的化合物类别。 驱动这项工作的互补机制和目标导向的方法允许在有机硅和催化研究的当前调查中进行独特的研究。 该小组正在开发复杂和高度通用的方法，用于聚合构建具有广泛用途的新小分子。更广泛的影响：本提案研究目标的调查将同时为从事这些项目的本科生，研究生，博士后研究员和访问学者提供必要的经验和科学知识。他们将学习合成技术，仪器分析，有机金属化学，纯化科学和解决问题的策略。 除了获得实验室技能外，Scheidt团队还定期举行每周一次的小组会议和每日一次的小组聚会，以讨论先前的结果并制定新的研究方向。每周的会议包括研究报告，对最近的高影响力的出版物进行简短的讨论，以及教学成长的化学问题。总的来说，在实验室的个人培训结合小，中，大型团体的形式，用于介绍和讨论化学主题提供了一个丰富的，充满活力和动态的学习环境。此外，实验室中代表性不足的群体的积极参与，创造了一个专业，充满活力和多民族的工作环境。Scheidt教授将继续组织和主持一年一度的芝加哥有机研讨会，并加强与西密歇根大学和芝加哥州立大学等机构的联系。该外展部分的重点是在整个化学系以及来自各种背景的学术和工业人员之间建立思想交流，预计将对社会产生独特而重大的影响。