CAREER: Catalytic, Multi-Component Reactions for the Synthesis of Heterocyclic Compounds

Scheidt教授正在开发利用催化多组分反应合成杂环化合物的新方法，在这种反应中，过渡金属配合物引发涉及类金属和含路易斯碱分子的级联反应。生成的反应中间体将被随后的环加成反应捕获。使用手性配体-过渡金属配合物作为催化剂将允许对映控制的杂环合成，而分子内变体将允许快速构建复杂的多环产物。Scheidt教授将开发新的宽平台分子可视化功能，旨在增强课堂和基于网络的学习，他将通过建立一个高中教师外展计划，促进这项技术向高中领域的转移。通过这个CAREER奖，有机和大分子化学项目支持了西北大学化学系Karl A. Scheidt教授的教学和研究工作。Scheidt教授正在开发新的方法来快速构建复杂的有机结构，利用金属配合物的不寻常的反应性和多功能性。他的方法在复杂分子结构的合成中具有普遍的应用前景，这些复杂分子结构通常具有重要的化学或生物特性。为了方便学生了解经常令人困惑的有机分子三维结构，Scheidt教授正在开发多功能和易于使用的分子结构可视化方法。他在整个有机化学课程中引入了这些技术，并通过建立高中教师外展计划促进了它们在高中环境中的应用。

Professor Scheidt is developing new methods for the synthesis of heterocyclic compounds utilizing catalytic, multi-component reactions in which a transition metal complex initiates a cascade involving a metallocarbenoid and Lewis base-containing molecules. The reactive intermediate generated will be trapped by a subsequent cycloaddition reaction. Use of chiral ligand-transition metal complexes as catalysts will allow enantiocontrolled heterocyclic synthesis, while intramolecular variants will permit the rapid construction of complex polycyclic products. Professor Scheidt will develop new broad-platform molecular visualization capabilities designed to enhance classroom and Web-based learning, and he will facilitate the transfer of this technology to the high school arena through establishment of a high school teacher outreach program.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research efforts of Professor Karl A. Scheidt, of the Department of Chemistry at Northwestern University. Professor Scheidt is developing novel methods for the rapid construction of complex organic structures, exploiting the unusual reactivity and versatility of metal complexes. His methods hold promise for general utility in the synthesis of the complex molecular structures often displaying important chemical or biological properties. In order to facilitate student learning about the often confusing three-dimensional structures of organic molecules, Professor Scheidt is developing versatile and accessible methods for visualization of molecular structures. He is introducing these techniques throughout the organic chemistry curriculum and is facilitating their usage in the high school setting through establishment of a high school teacher outreach program.