CAREER: Catalytic, Multi-Component Reactions for the Synthesis of Heterocyclic Compounds

职业：用于合成杂环化合物的催化多组分反应

• 批准号: 0348979
• 负责人: Karl Scheidt
• 金额: $ 53.1万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0348979&HistoricalAwards=false
• 关键词: CAREER; Catalytic; Multi; Component; Reactions

Professor Scheidt is developing new methods for the synthesis of heterocyclic compounds utilizing catalytic, multi-component reactions in which a transition metal complex initiates a cascade involving a metallocarbenoid and Lewis base-containing molecules. The reactive intermediate generated will be trapped by a subsequent cycloaddition reaction. Use of chiral ligand-transition metal complexes as catalysts will allow enantiocontrolled heterocyclic synthesis, while intramolecular variants will permit the rapid construction of complex polycyclic products. Professor Scheidt will develop new broad-platform molecular visualization capabilities designed to enhance classroom and Web-based learning, and he will facilitate the transfer of this technology to the high school arena through establishment of a high school teacher outreach program.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research efforts of Professor Karl A. Scheidt, of the Department of Chemistry at Northwestern University. Professor Scheidt is developing novel methods for the rapid construction of complex organic structures, exploiting the unusual reactivity and versatility of metal complexes. His methods hold promise for general utility in the synthesis of the complex molecular structures often displaying important chemical or biological properties. In order to facilitate student learning about the often confusing three-dimensional structures of organic molecules, Professor Scheidt is developing versatile and accessible methods for visualization of molecular structures. He is introducing these techniques throughout the organic chemistry curriculum and is facilitating their usage in the high school setting through establishment of a high school teacher outreach program.

Scheidt教授正在开发利用催化、多组分反应合成杂环化合物的新方法，其中过渡金属络合物引发涉及类卡宾和含刘易斯碱分子的级联反应。所产生的反应性中间体将被随后的环加成反应捕获。使用手性配体-过渡金属配合物作为催化剂将允许对映体控制的杂环合成，而分子内变体将允许快速构建复杂的多环产物。Scheidt教授将开发新的宽平台分子可视化能力，旨在提高课堂和基于网络的学习，他将通过建立一个高中教师外展计划，促进这项技术转移到高中竞技场。西北大学化学系的Scheidt说。Scheidt教授正在开发快速构建复杂有机结构的新方法，利用金属络合物的不寻常的反应性和多功能性。他的方法有望在复杂分子结构的合成中得到普遍应用，这些复杂分子结构通常显示出重要的化学或生物学性质。为了帮助学生了解有机分子的三维结构，Scheidt教授正在开发用于分子结构可视化的通用和可访问的方法。他在整个有机化学课程中引入这些技术，并通过建立高中教师推广计划促进其在高中环境中的使用。