CAREER: Catalytic, Multi-Component Reactions for the Synthesis of Heterocyclic Compounds

Scheidt教授正在开发利用催化多组分反应合成杂环化合物的新方法，在这些反应中，过渡金属络合物引发涉及金属卡宾和Lewis碱分子的级联反应。生成的活性中间体将被随后的环加成反应捕获。使用手性配体-过渡金属络合物作为催化剂将允许对映体控制的杂环合成，而分子内变体将允许快速构建复杂的多环产物。Scheidt教授将开发新的广泛平台的分子可视化能力，旨在增强课堂和基于网络的学习，他将通过建立一个高中教师外展计划，促进将这项技术转移到高中舞台上。通过这个职业奖项，有机和高分子化学计划正在支持西北大学化学系的Karl A.Scheidt教授的教学和研究努力。Scheidt教授正在开发快速构建复杂有机结构的新方法，利用金属络合物不同寻常的反应性和多功能性。他的方法有望在合成复杂的分子结构方面具有普遍的实用价值，这些分子结构往往显示出重要的化学或生物特性。为了促进学生学习经常令人困惑的有机分子的三维结构，Scheidt教授正在开发通用的、可访问的分子结构可视化方法。他在整个有机化学课程中介绍这些技术，并通过建立一个高中教师推广计划来促进它们在高中环境中的使用。

Professor Scheidt is developing new methods for the synthesis of heterocyclic compounds utilizing catalytic, multi-component reactions in which a transition metal complex initiates a cascade involving a metallocarbenoid and Lewis base-containing molecules. The reactive intermediate generated will be trapped by a subsequent cycloaddition reaction. Use of chiral ligand-transition metal complexes as catalysts will allow enantiocontrolled heterocyclic synthesis, while intramolecular variants will permit the rapid construction of complex polycyclic products. Professor Scheidt will develop new broad-platform molecular visualization capabilities designed to enhance classroom and Web-based learning, and he will facilitate the transfer of this technology to the high school arena through establishment of a high school teacher outreach program.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research efforts of Professor Karl A. Scheidt, of the Department of Chemistry at Northwestern University. Professor Scheidt is developing novel methods for the rapid construction of complex organic structures, exploiting the unusual reactivity and versatility of metal complexes. His methods hold promise for general utility in the synthesis of the complex molecular structures often displaying important chemical or biological properties. In order to facilitate student learning about the often confusing three-dimensional structures of organic molecules, Professor Scheidt is developing versatile and accessible methods for visualization of molecular structures. He is introducing these techniques throughout the organic chemistry curriculum and is facilitating their usage in the high school setting through establishment of a high school teacher outreach program.