New Lewis Bases for Chemical Catalysis

用于化学催化的新路易斯碱

• 批准号: 1152010
• 负责人: Karl Scheidt
• 金额: $ 47.1万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152010&HistoricalAwards=false
• 关键词: New; Lewis; Bases; Chemical; Catalysis

In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Karl A. Scheidt, Chemistry Department of Northwestern University, will investigate the synthesis and study of new Lewis bases as catalysts for chemical reactions. A primary focus will be on N-heterocyclic carbenes (NHCs). These Lewis bases have been developed as metal-free catalysts as well as being employed as ligands to generate chiral metal complexes. However, there is a dearth of new, chiral NHCs and there have been few mechanistic investigations of NHC-catalyzed processes. This project will focus on the development of new families of chiral NHCs as ligands and catalysts. The different phases of the investigation include a) synthesis and characterization of new classes of chiral N-heterocyclic carbenes and the evaluation/benchmarking of these NHCs in established catalytic processes, b) exploring/validating carbene catalysis mechanisms, and c) studies geared towards understanding the structure reactivity relationships of new catalysts for the purpose of predicting and controlling the outcome of Lewis base processes. These advances will ultimately expedite the ability to synthesize natural products, pharmaceuticals and fine chemicals with maximum efficiency and minimal impact on the environment. The development of new catalysts that promote high value reactions is a crucial enterprise that impacts a wide range of scientific endeavors with biological and pharmacological endpoints. The investigations to be carried out on this project will advance our knowledge of Lewis base and metal catalysis, as well as structure reactivity relationships that are the foundation of modern chemical science. These studies provide training for s diverse set of students and postdoctoral fellows. The expected skills acquired by graduate and undergraduate students driving these projects include advanced problem solving, chemical synthesis, and mechanistic organic chemistry/catalysis.

本项目由美国西北大学化学系的Karl A. Scheidt教授资助，将对新型路易斯碱作为化学反应催化剂的合成和研究进行研究。主要的焦点将是n -杂环碳烯（NHCs）。这些路易斯碱已被开发为无金属催化剂，并被用作配体来产生手性金属配合物。然而，缺乏新的手性NHCs，并且对NHCs催化过程的机理研究很少。本项目将重点开发新的手性NHCs家族作为配体和催化剂。研究的不同阶段包括：a)新手性n -杂环羰基的合成和表征，以及这些NHCs在已建立的催化过程中的评价/基准，b)探索/验证羰基催化机制，以及c)旨在了解新催化剂的结构反应关系的研究，以预测和控制路易斯碱过程的结果。这些进步最终将加速以最高效率和对环境影响最小的方式合成天然产物、药品和精细化学品的能力。开发促进高价值反应的新型催化剂是一项至关重要的事业，它影响着生物学和药理学领域的广泛科学努力。在这个项目上进行的研究将提高我们对刘易斯碱和金属催化的认识，以及作为现代化学科学基础的结构反应关系。这些研究为不同类型的学生和博士后提供培训。推动这些项目的研究生和本科生期望获得的技能包括高级问题解决，化学合成和机械有机化学/催化。