Sphingolipids in gonococcal infection

淋球菌感染中的鞘脂

• 批准号: 251288492
• 负责人: Professor Dr. Thomas Rudel
• 金额: --
• 依托单位: Lehrstuhl für Mikrobiologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/251288492?language=en
• 关键词: Sphingolipids; gonococcal; infection

Disseminated gonococcal infection is a serious complication caused by the bacteremic spread of Neisseria gonorrhoeae. Gonococci rapidly invade epithelial and endothelial cells via the scavenger receptor SREC. We could recently demonstrate, that SREC-dependent invasion requires intact detergent-resistant microdomains, caveolin 1 phosphorylation and the involvement of several signaling molecules, including neutral sphingomyelinase 2 (NSMase2), but not of acid SMase (ASMase). Published data already suggested ASMase as important enzyme involved in the interaction of gonococci with epithelial and phagocytic cells during acute infection. The major objective of the current project therefore is to understand the role of sphingolipids and NSMases in the course of bacterial invasion during disseminated gonococccal infection.

播散性淋球菌感染是由淋球菌菌血症传播引起的严重并发症。淋球菌通过清道夫受体SREC迅速侵入上皮和内皮细胞。我们最近可以证明，SREC依赖的入侵需要完整的洗涤剂抗性微结构域，小窝蛋白1磷酸化和几个信号分子的参与，包括中性鞘磷脂酶2（NSMase 2），但不是酸性SMase（ASMase）。已发表的数据表明，ASMase是淋球菌与上皮细胞和吞噬细胞在急性感染期间相互作用的重要酶。因此，本项目的主要目标是了解鞘脂和NSM酶在播散性淋球菌感染过程中细菌入侵过程中的作用。