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Research Infrastructure: MRI: Acquisition of a Biomolecular Imaging System for Research and Education

研究基础设施：MRI：获取用于研究和教育的生物分子成像系统

基本信息

批准号：
2214573
负责人：
Emil Khisamutdinov
金额：
$ 18.43万
依托单位：
Ball State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-10-01 至 2025-09-30
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2214573&HistoricalAwards=false
关键词：
Research Infrastructure MRI Acquisition Biomolecular

项目摘要

An award is made to Ball State University (BSU) to support the acquisition of a laser-based biomolecular imaging system to advance biochemical and molecular biology research projects, as well as to improve the quality and expand the scope of research and student training. This new biomolecular imaging system is an essential tool which will allow researchers to detect, visualize, and quantify proteins, nucleic acids, and other biomolecules at the molecular and cellular levels, opening a wide range of possibilities for hands-on experiences for a diverse group of next generation of scientists and teaching students to think critically with problem-based learning modules. The biomolecular imager will cultivate significant societal impact by becoming a shared resource open to investigators from all areas of scientific research not only across the departments at BSU but also from regional universities including Anderson University, Taylor University, Indiana Wesleyan University, as well as high schools such as The Indiana Academy for Science, Mathematics, and Humanities. Using this unique instrumentation, faculty in BSU’s Chemistry and Biology Departments will broaden the dissemination of their research and knowledge by actively participating in several outreach programs. These programs include the Chemistry Research Immersion Summer Program, Louis Stokes Alliance for Minority Participation, and a “DNA-Day” activity for high school students to encourage them to consider careers in STEM disciplines.This state-of-the-art instrument supports multiple imaging modes, including red/green/blue and long/short wavelengths of near-infrared fluorescence, optical densitometry of proteins in stained gels, and phosphor imaging. At least seven research groups will use the biomolecular imaging system from BSU’s Chemistry and Biology Departments for individual research, research training programs, and teaching. The new system will advance investigators’ broad and multidisciplinary research objectives, which include (1) the design of various Logic Gated nucleic acid complexes; (2) the development of novel molecular probes derived from a natural glycolipid; (3) understanding of the mechanism of apolipoprotein degradation with relevance to cholesterol related pathologies; (4) uncovering details of the mechanism of modulation of G-quadruplex helicase activity by non-coding RNAs; (5) the development of modern expression systems for novel enzymatic catalysts; (6) elucidation of the roles RNA modification plays in fungi; and (7) searching for a mechanistic explanation for how mitoNEET (mitochondrial membrane protein) serves as a redox sensor across evolution. The critical capabilities of this new instrument, such as exceptional imaging quality, high image resolution, and increased accuracy of quantification, will benefit the faculty's research goals. The outcome of the research projects will be published in peer-reviewed journals and presented at regional, national, and international scientific meetings within investigators’ respective fields.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

一个奖项是由球州立大学（BSU），以支持收购基于激光的生物分子成像系统，以推进生物化学和分子生物学研究项目，以及提高质量和扩大研究和学生培训的范围。这种新的生物分子成像系统是一种必不可少的工具，它将使研究人员能够在分子和细胞水平上检测，可视化和量化蛋白质，核酸和其他生物分子，为各种各样的动手经验打开了各种可能性下一代科学家和教学生批判性地思考基于问题的学习模块。生物分子成像仪将培养显着的社会影响，成为一个共享的资源，开放给所有领域的科学研究，不仅在BSU的部门，而且从区域大学，包括安德森大学，泰勒大学，印第安纳州卫斯理大学，以及高中，如印第安纳州科学，数学和人文学院。使用这种独特的仪器，在BSU的化学和生物系的教师将扩大他们的研究和知识的传播，积极参与几个推广计划。这些项目包括化学研究浸入式暑期项目、Louis Stokes少数民族参与联盟以及针对高中生的“DNA日”活动，以鼓励他们考虑STEM学科的职业生涯。这款最先进的仪器支持多种成像模式，包括红/绿色/蓝色和长/短波长的近红外荧光、染色凝胶中蛋白质的光密度测定和磷光体成像。至少有七个研究小组将使用BSU化学和生物系的生物分子成像系统进行个人研究，研究培训计划和教学。新系统将推进研究者广泛和多学科的研究目标，包括（1）各种逻辑门控核酸复合物的设计;（2）天然糖脂衍生的新型分子探针的开发;（3）了解载脂蛋白降解机制与胆固醇相关病理学的关系;（4）开发新的逻辑门控核酸复合物。（4）揭示非编码RNA调节G-四链体解旋酶活性的机制;（5）开发新型酶催化剂的现代表达系统;（6）阐明RNA修饰在真菌中的作用;以及（7）寻找线粒体膜蛋白（mitoNEET）如何在进化过程中充当氧化还原传感器的机制解释。这种新仪器的关键功能，如卓越的成像质量，高图像分辨率和提高的定量准确性，将有利于教师的研究目标。研究项目的成果将发表在同行评审的期刊上，并在研究人员各自领域的地区，国家和国际科学会议上发表。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。