Research Infrastructure: MRI: Acquisition of BioLayer Interferometer Octet RH16 for Label-Free Detection of Biomolecular Interactions

研究基础设施：MRI：获取 BioLayer 干涉仪八位组 RH16，用于无标记检测生物分子相互作用

• 批准号: 2215833
• 负责人: Zhihao Zhuang
• 金额: $ 36.56万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215833&HistoricalAwards=false
• 关键词: Research; Infrastructure; MRI; Acquisition; BioLayer

An award is made to University of Delaware to acquire an Octet RH16 that allows label-free detection of biomolecular interactions central to modern biochemical, biophysical, materials and biopharmaceutical researches. As protein interactions with a variety of biomolecules including other proteins, nucleotides, carbohydrates and small molecules are fundamental for understanding biological processes, graduate and undergraduate trainees will use the instrument frequently and gain hands-on experience of using the instrument. The acquisition of an Octet RH16 will be a critical resource for Sartorius BioLayer Interferometer measurement and significantly impact the research and training infrastructure at the University of Delaware, Delaware State University and schools in the Delaware Valley, including Morgan State University, Haverford College, Villanova University, and Rowan University. The Octet RH16 will be used broadly in research and undergraduate training programs across multiple campuses. We plan to actively integrate the instrument into the research and teaching environments to increase student involvement in their own learning at both University of Delaware and the participating primarily undergraduate institutions (PUIs). The research and training opportunities provided by this Octet RH16 to a large number of underrepresented minority and female students are expect to positively impact their future careers in STEM fields.The proposed Octet RH16 will support the research of 20 groups at participating universities and colleges, reaching across multiple departments and colleges (chemistry and biochemistry, biological sciences, materials sciences, and chemical and biomolecular engineering). The groups involved in this research represent a wide range of research areas, including biochemistry, biophysics, chemical biology, molecular biology, materials science and biomolecular engineering. The access to an Octet RH16 will enable researchers at UD and surrounding PUIs and HBCUs in tackling cutting-edge and interdisciplinary research problems, facilitating interactions among researchers and forging new collaborations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

特拉华大学获得了一台八位组RH16，它允许对现代生化、生物物理、材料和生物制药研究的核心生物分子相互作用进行无标记检测。由于蛋白质与包括其他蛋白质、核苷酸、碳水化合物和小分子在内的各种生物分子的相互作用是理解生物过程的基础，研究生和本科生将经常使用该仪器，并获得使用该仪器的实践经验。收购Octet RH16将是Sartorius BioLayer干涉仪测量的关键资源，并对特拉华大学、特拉华州立大学和特拉华山谷学校的研究和培训基础设施产生重大影响，包括摩根州立大学、哈弗福德学院、维拉诺瓦大学和罗文大学。OCTET RH16将被广泛用于多个校区的研究和本科培训项目。我们计划积极地将该仪器整合到研究和教学环境中，以增加特拉华大学和参与的主要是本科生机构(PUI)的学生对自己的学习的参与。本次OCTET RH16为大量未被充分代表的少数族裔和女性学生提供的研究和培训机会，预计将对他们未来在STEM领域的职业生涯产生积极影响。拟议的OCTET RH16将支持参与大学和学院的20个小组的研究，涉及多个系和学院(化学和生物化学、生物科学、材料科学、化学和生物分子工程)。参与这项研究的小组代表了广泛的研究领域，包括生物化学、生物物理、化学生物学、分子生物学、材料科学和生物分子工程。使用OCTET RH16将使UD和周围的PUI和HBCU的研究人员能够解决尖端和跨学科的研究问题，促进研究人员之间的互动和建立新的合作。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。