Emotional recognition and processing in patients with insula lesions

岛叶病变患者的情绪识别和处理

• 批准号: 252646756
• 负责人: Professor Dr. Martin Lotze
• 金额: --
• 依托单位: Klinik und Poliklinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/252646756?language=en
• 关键词: Emotional; recognition; processing; patients; insula

Imaging studies contributed to the knowledge that the insula is part of interoceptive processing. These findings support models postulating that the integration of environmental signals, together with physiologic changes elicited by these signals, represent a central mechanism for the recognition and experience of emotions. Astonishingly, group studies supporting this theory are widely absent. Over the last years we identified a group of more than 30 patients with ischemic unilateral lesions of the insula, we intend to recruit more of these patients from our university hospital, and we will investigate the mentioned research questions on this patient population. We intend to use neuropsychological testing, psychophysiology and structural and functional magnetic resonance imaging. By combining the lesion model (specific deficits) and functional investigation (changes in functional representation and physiology) for the first time, we will be able to comprehensively describe the role of the insula in emotional processing.

影像学研究有助于认识到岛叶是内感受处理的一部分。这些发现支持模型假设环境信号的整合以及这些信号引起的生理变化代表了情绪识别和体验的中心机制。令人惊讶的是，支持这一理论的团体研究却普遍缺失。在过去的几年里，我们确定了一组超过 30 名患有单侧岛叶缺血性病变的患者，我们打算从我们的大学医院招募更多这样的患者，我们将针对该患者群体调查上述研究问题。我们打算使用神经心理学测试、心理生理学以及结构和功能磁共振成像。通过首次将病变模型（特定缺陷）和功能研究（功能表征和生理学的变化）结合起来，我们将能够全面描述岛叶在情绪处理中的作用。

项目成果

Emotionsstörungen in der Rehabilitation

康复中的情绪障碍

• DOI: 10.1055/a-0596-6654
• 发表时间: 2018
• 期刊: neuroreha
• 作者: Lotze M.

Brain imaging of chill reactions to pleasant and unpleasant sounds

• DOI: 10.1016/j.bbr.2019.112417
• 发表时间: 2020-02-17
• 期刊: BEHAVIOURAL BRAIN RESEARCH
• 影响因子: 2.7
• 作者: Klepzig, K.;Horn, U.;Lotze, M.
• 通讯作者: Lotze, M.

Funktionelle Anatomie der Emotionsstörungen

情绪障碍的功能解剖

• DOI: 10.1055/a-0596-6685
• 发表时间: 2018
• 期刊: neuroreha
• 作者: Lotze M.