I-Corps: Bandage-integrated platform for feedback-mediated wound therapy

这个i-Corps项目的更广泛影响是开发了一种先进的伤口护理技术，该技术可以在分子诊断的指导下提供个性化的伤口护理疗法，以降低成本改善患者的预后。伤口护理管理是一项重大的医疗挑战，仅在美国就有600多万患者，导致巨大的经济和医疗成本。医疗保险伤口成本预测从28.1美元到968亿美元不等，其中手术和糖尿病伤口是最昂贵的。日益增加的伤口患病率导致了经济负担，减少了活动能力，并显著降低了患者的生活质量。通过提供实时监测和治疗，拟议的平台可能会减少并发症的发生，从而降低慢性伤口发展的风险。此外，使用拟议平台的及时治疗干预可能允许有效的伤口管理，降低创伤性截肢和死亡率的风险。个性化伤口治疗平台的商业化也可能改善传统上依从性较低的慢性护理。此外，收集的医疗数据可以使预测性伤口分析进一步改善患者结果。这些预测可能使伤口护理提供者提供更准确的评估和更好的治疗方案，从而提高临床疗效并减少社会负担。这个i-Corps项目基于一个整合平台的开发，该平台为个性化伤口护理提供反馈中介的伤口治疗。新医疗技术开发和验证中最大的挑战之一是患者依从性差，这导致临床试验中的疗效验证受到影响。材料科学领域的技术进步使伤口护理可穿戴平台的开发成为可能。然而，这些平台并不是真正的整合，从而限制了它们的实际部署。该技术使用一种新的制造方法来实现隐形设备的整合平台。该方法产生了高度灵活的平台，能够控制变形以容纳刚性电路元件，同时保持灵活性以满足用户的舒适性。拟议的平台将空间伤口监测和治疗与反馈机制相结合，以提高治疗效率。该平台测量多个伤口生物标志物(尿酸、乳酸、pH和温度)的空间变化，以获得关于伤口健康的完整信息。这些信息随后被用来通过光生物调节在空间上治疗伤口。该平台的合规性允许在较长时间内直接放置在伤口上，提供实时监测和治疗，而不会导致患者不适。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this I-Corps project is the development of an advanced wound care technology that may provide personalized wound care therapy, guided by molecular diagnostics, to improve patient outcomes at reduced cost. Wound care management is a major healthcare challenge with over 6 million sufferers in the US alone, leading to huge economic and health costs. Medicare wound cost projections ranged from $28.1 to $96.8 billion, with surgical and diabetic wounds being the most expensive. The increasing wound prevalence has resulted in economic burden, reduced mobility, and significantly reduced quality of life for the patient. By offering real-time monitoring and therapy, the proposed platform may reduce the occurrence of complications, thus decreasing the risk of chronic wound development. In addition, timely therapeutic intervention using the proposed platform may allow for efficient wound management, decreasing the risk of traumatic amputations and mortality. Commercialization of a personalized wound therapy platform also may improve chronic care, which traditionally has low adherence. Further, the collected medical data may enable predictive wound analytics to further improve patient outcomes. These predictions may enable wound care providers to offer more accurate assessments and better treatment regimens, resulting in improved clinical efficacy and reduced societal burdens.This I-Corps project is based on the development of a conformable platform that provides feedback-mediated wound therapy for personalized wound care. One of the biggest challenges in the development and validation of a new medical technology is poor patient adherence, which results in compromised efficacy validation in clinical trials. Technological advancements in the field of material science have enabled the development of wearable platforms for wound care. However, these platforms are not truly conformable, thus limiting their practical deployment. The proposed technology uses a novel fabrication methodology to realize a conformable platform for imperceptible devices. The methodology results in a highly flexible platform that enables controlled deformation to accommodate rigid circuit components, while maintaining flexibility for user comfort. The proposed platform combines spatial wound monitoring and therapy with a feedback mechanism to improve therapeutic efficiencies. The platform measures spatial changes in multiple wound biomarkers (uric acid, lactate, pH, and temperature) to obtain complete information on wound health. The information is subsequently used to treat the wound spatially with photobiomodulation. The conformability of the platform allows for direct placement over the wounds for extended periods of time, providing real-time monitoring and therapy without causing patient discomfort.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.