I-Corps: Bandage-integrated platform for feedback-mediated wound therapy

I-Corps：用于反馈介导伤口治疗的绷带集成平台

• 批准号: 2230621
• 负责人: Vladimir Pozdin
• 金额: $ 5万
• 依托单位: Florida International University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2230621&HistoricalAwards=false
• 关键词: Corps; Bandage; integrated; platform; feedback

The broader impact of this I-Corps project is the development of an advanced wound care technology that may provide personalized wound care therapy, guided by molecular diagnostics, to improve patient outcomes at reduced cost. Wound care management is a major healthcare challenge with over 6 million sufferers in the US alone, leading to huge economic and health costs. Medicare wound cost projections ranged from $28.1 to $96.8 billion, with surgical and diabetic wounds being the most expensive. The increasing wound prevalence has resulted in economic burden, reduced mobility, and significantly reduced quality of life for the patient. By offering real-time monitoring and therapy, the proposed platform may reduce the occurrence of complications, thus decreasing the risk of chronic wound development. In addition, timely therapeutic intervention using the proposed platform may allow for efficient wound management, decreasing the risk of traumatic amputations and mortality. Commercialization of a personalized wound therapy platform also may improve chronic care, which traditionally has low adherence. Further, the collected medical data may enable predictive wound analytics to further improve patient outcomes. These predictions may enable wound care providers to offer more accurate assessments and better treatment regimens, resulting in improved clinical efficacy and reduced societal burdens.This I-Corps project is based on the development of a conformable platform that provides feedback-mediated wound therapy for personalized wound care. One of the biggest challenges in the development and validation of a new medical technology is poor patient adherence, which results in compromised efficacy validation in clinical trials. Technological advancements in the field of material science have enabled the development of wearable platforms for wound care. However, these platforms are not truly conformable, thus limiting their practical deployment. The proposed technology uses a novel fabrication methodology to realize a conformable platform for imperceptible devices. The methodology results in a highly flexible platform that enables controlled deformation to accommodate rigid circuit components, while maintaining flexibility for user comfort. The proposed platform combines spatial wound monitoring and therapy with a feedback mechanism to improve therapeutic efficiencies. The platform measures spatial changes in multiple wound biomarkers (uric acid, lactate, pH, and temperature) to obtain complete information on wound health. The information is subsequently used to treat the wound spatially with photobiomodulation. The conformability of the platform allows for direct placement over the wounds for extended periods of time, providing real-time monitoring and therapy without causing patient discomfort.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

I-Corps项目更广泛的影响是发展先进的伤口护理技术，可以提供个性化的伤口护理治疗，在分子诊断的指导下，以降低成本改善患者的治疗效果。伤口护理管理是一项重大的医疗保健挑战，仅在美国就有600多万患者，导致巨大的经济和健康成本。医疗保险伤口成本预测从281亿美元到968亿美元不等，手术和糖尿病伤口是最昂贵的。伤口流行率的增加导致了经济负担，减少了行动能力，并显著降低了患者的生活质量。通过提供实时监测和治疗，该平台可以减少并发症的发生，从而降低慢性伤口发展的风险。此外，使用所提出的平台进行及时的治疗干预可以实现有效的伤口管理，降低创伤性截肢和死亡的风险。个性化伤口治疗平台的商业化也可能改善传统上依从性较低的慢性护理。此外，收集到的医疗数据可以用于预测伤口分析，进一步改善患者的治疗效果。这些预测可能使伤口护理提供者提供更准确的评估和更好的治疗方案，从而提高临床疗效，减少社会负担。I-Corps项目的基础是开发一个兼容的平台，为个性化伤口护理提供反馈介导的伤口治疗。开发和验证新医疗技术的最大挑战之一是患者依从性差，这导致临床试验中的疗效验证受到损害。材料科学领域的技术进步使伤口护理可穿戴平台的发展成为可能。然而，这些平台并不是真正兼容的，因此限制了它们的实际部署。该技术采用了一种新颖的制造方法来实现不易察觉器件的兼容平台。该方法产生了一个高度灵活的平台，可以控制变形以适应刚性电路组件，同时保持用户舒适度的灵活性。该平台将空间伤口监测和治疗与反馈机制相结合，以提高治疗效率。该平台测量多个伤口生物标志物（尿酸、乳酸、pH和温度）的空间变化，以获得伤口健康的完整信息。这些信息随后被用于光生物调节的伤口空间治疗。平台的一致性允许在伤口上直接放置较长时间，提供实时监测和治疗，而不会引起患者不适。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。