I-Corps: Bandage-integrated platform for feedback-mediated wound therapy

该I-Corps项目的更广泛影响是开发了一种先进的伤口护理技术，该技术可以在分子诊断的指导下提供个性化的伤口护理治疗，从而以更低的成本改善患者的预后。伤口护理管理是一项重大的医疗保健挑战，仅在美国就有超过600万患者，导致巨大的经济和健康成本。医疗保险伤口成本预测从281亿美元到968亿美元不等，手术和糖尿病伤口是最昂贵的。伤口患病率的增加导致了经济负担、活动能力的降低以及患者生活质量的显著降低。通过提供实时监测和治疗，所提出的平台可以减少并发症的发生，从而降低慢性伤口发展的风险。此外，使用所提出的平台进行及时的治疗干预可以实现有效的伤口管理，降低创伤性截肢和死亡率的风险。个性化伤口治疗平台的商业化也可以改善传统上依从性低的慢性护理。此外，所收集的医疗数据可以实现预测性伤口分析以进一步改善患者结果。这些预测可以使伤口护理提供者提供更准确的评估和更好的治疗方案，从而提高临床疗效，减少社会负担。这个I-Corps项目是基于一个整合平台的开发，提供反馈介导的伤口治疗个性化的伤口护理。新医疗技术开发和验证的最大挑战之一是患者依从性差，这导致临床试验中的有效性验证受到影响。材料科学领域的技术进步使得伤口护理可穿戴平台的开发成为可能。然而，这些平台并不是真正的整合，从而限制了它们的实际部署。所提出的技术使用一种新的制造方法来实现一个不可感知设备的整合平台。该方法导致高度柔性的平台，其使得能够控制变形以适应刚性电路部件，同时保持用户舒适的柔性。所提出的平台将空间伤口监测和治疗与反馈机制相结合，以提高治疗效率。该平台可测量多种伤口生物标志物（尿酸、乳酸盐、pH值和温度）的空间变化，以获得有关伤口健康的完整信息。该信息随后用于用光生物调节在空间上治疗伤口。该平台的一致性允许直接放置在伤口上很长一段时间，提供实时监测和治疗，而不会引起患者不适。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

The broader impact of this I-Corps project is the development of an advanced wound care technology that may provide personalized wound care therapy, guided by molecular diagnostics, to improve patient outcomes at reduced cost. Wound care management is a major healthcare challenge with over 6 million sufferers in the US alone, leading to huge economic and health costs. Medicare wound cost projections ranged from $28.1 to $96.8 billion, with surgical and diabetic wounds being the most expensive. The increasing wound prevalence has resulted in economic burden, reduced mobility, and significantly reduced quality of life for the patient. By offering real-time monitoring and therapy, the proposed platform may reduce the occurrence of complications, thus decreasing the risk of chronic wound development. In addition, timely therapeutic intervention using the proposed platform may allow for efficient wound management, decreasing the risk of traumatic amputations and mortality. Commercialization of a personalized wound therapy platform also may improve chronic care, which traditionally has low adherence. Further, the collected medical data may enable predictive wound analytics to further improve patient outcomes. These predictions may enable wound care providers to offer more accurate assessments and better treatment regimens, resulting in improved clinical efficacy and reduced societal burdens.This I-Corps project is based on the development of a conformable platform that provides feedback-mediated wound therapy for personalized wound care. One of the biggest challenges in the development and validation of a new medical technology is poor patient adherence, which results in compromised efficacy validation in clinical trials. Technological advancements in the field of material science have enabled the development of wearable platforms for wound care. However, these platforms are not truly conformable, thus limiting their practical deployment. The proposed technology uses a novel fabrication methodology to realize a conformable platform for imperceptible devices. The methodology results in a highly flexible platform that enables controlled deformation to accommodate rigid circuit components, while maintaining flexibility for user comfort. The proposed platform combines spatial wound monitoring and therapy with a feedback mechanism to improve therapeutic efficiencies. The platform measures spatial changes in multiple wound biomarkers (uric acid, lactate, pH, and temperature) to obtain complete information on wound health. The information is subsequently used to treat the wound spatially with photobiomodulation. The conformability of the platform allows for direct placement over the wounds for extended periods of time, providing real-time monitoring and therapy without causing patient discomfort.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.