CAREER: Frequency Comb-Based Multidimensional Coherent Spectroscopy and Microscopy at the Nanoscale

在化学系化学测量和成像（CMI）项目的支持下，来自圣克拉拉大学的Bachana Lomsadze正在开发一种新工具，该工具将近场光学显微镜与频率梳多维相干光谱相结合，以提高超分辨率成像的光谱和空间分辨率，从而更好地了解二维材料的化学和物理性质。了解材料在小长度尺度上的性质对于结构变化如何影响化学反应和特异性以及局部能量转移至关重要。Lomsadze博士和他的团队正在开发一种新的工具，可以提供二维过渡金属二硫化物的空间和光谱解析的化学和物理信息。他们的发现可以在单个粒子水平上更好地理解材料的化学和物理特性，有助于开发量子器件，并在化学传感或生物医学成像等实验室之外的应用中找到用途。Lomsadze博士还为非理科生开发课堂活动，帮助学生理解和欣赏影响当今社会的基础科学和技术。Lomsadze实验室将结合近场光学显微镜和频率梳多维相干光谱学，着眼于提高红外光谱区域二维材料超分辨率成像的光谱和空间分辨率。虽然目前的方法可以成功地评估二维材料的化学和物理性质，但大多数方法受到大信号背景、慢采集时间、空间分辨率或光谱分辨率的限制。Lomsadze小组正在开发一种方法，这种方法有可能产生每像素二维相干光谱，在几秒钟内收集，具有高（即几十纳米）的空间分辨率和梳状光谱分辨率。这些在空间和光谱分辨率方面的改进可能会带来关于材料的化学、物理和光学特性的新信息，并对从法医到生物医学成像和现场分析等许多领域产生影响。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With support from the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry, Bachana Lomsadze from Santa Clara University is developing a new tool that combines near-field optical microscopy with frequency comb multidimensional coherent spectroscopy to improve both the spectral and spatial resolutions for super resolution imaging for better understanding of the chemical and physical properties of two dimensional materials. Understanding material properties at small length scales is critical for correlating how structural variations influence chemical reactions and specificity as well as energy transfer locally. Dr. Lomsadze and his group are developing a new tool that provides spatially and spectrally resolved chemical and physical information about the two-dimensional transition metal dichalcogenides. Their discoveries could lead to better understanding of the chemical and physical properties of materials on a single particle level, aid efforts to develop quantum devices, and find use outside the laboratory for applications such as chemical sensing or biomedical imaging. Dr. Lomsadze is also developing classroom activities for non-science majors to help students understand and appreciate basic science and technology that is impacting society today.The Lomsadze lab will combine a near-field optical microscope with frequency comb multidimensional coherent spectroscopy with an eye toward improving the spectral and spatial resolution for super resolution imaging of two dimensional materials in the infrared spectral region. While current methods can successfully evaluate the chemical and physical properties of two dimensional materials routinely, most methods are limited by large signal backgrounds, slow acquisition times, spatial resolution, or spectral resolution. The Lomsadze group is developing methods that have the potential to result in two-dimensional coherent spectra per pixel, that are collected in seconds, with high (i.e., tens of nm) spatial resolution, and with comb spectral resolution. These improvements in spatial and spectral resolution could lead to new information about the chemical, physical, and optical properties of materials with implications in many fields ranging from forensics to biomedical imaging and field analysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.