CAREER: Acousto-Bioelectronics

职业：声学生物电子学

• 批准号: 2245090
• 负责人: Albert Kim
• 金额: $ 50万
• 依托单位: University of South Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-10-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2245090&HistoricalAwards=false
• 关键词: CAREER; Acousto; Bioelectronics

This CAREER project is a part of a global effort to conquer cancer, the second leading cause of death. Despite the enormous investments in research and development, there have been scant clinical successes as a viable cancer therapy. Recent advancements in cancer therapy have resulted in the emergence of implanted medical devices (IMDs) into feasible medicines, owing to their capacity to localize treatments, albeit limited in numbers. However, currently available IMDs-mediated cancer treatments are often confined to a single, non-replenishable administration per therapy. These limitations, along with a number of risks such as painful surgery, infection risk in the catheter, and device failure, have generally hampered the usage of IMDs in cancer treatment. More importantly, cancer cannot be effectively managed with a single therapeutic approach due to its complex, diverse, and heterogeneous nature. As such, this CAREER project investigates a versatile engineering solution in the form of an acoustically driven implantable microsystem that provides a tailored combination of multimodal cancer therapeutics: oxygen, chemotherapy drugs, and light. Combined, this project aims to establish the field of ‘Acousto-Bioelectronics’ that spurs new theory and understanding for the next generation of IMDs. Furthermore, the project integrates the research with educational venues by mentoring graduate and undergraduate students, with a particular emphasis on the underrepresented minorities and female students, developing interdisciplinary curricula, and creating pedagogical resources ranging from fundamental theory to hands-on activities.While IMDs are transforming modern healthcare, they are unable to cure cancer at the moment due to their short lifetime. This is compounded by the fact that many cancers can relapse or spread metastatically. The overarching goal of this CAREER project is to leverage cross-cutting innovations from the domain of engineering and healthcare fields to create an ultrasonically-powered implantable microsystem that enables a tailored combination of multimodal cancer therapies. This study (1) elucidates the untapped potential of Platonic solid structures for a highly efficient omnidirectional ultrasonic powering scheme for IMDs, utilizing a unique 3D-printable barium titanate ultrasonic receiver. (2) Providing adequate power via ultrasound, the microsystem enables the in-situ generation of oxygen, cisplatin, and light through controlled electrochemical and photochemical processes. It is hence called Oxygen Enhanced Chemo-Photodynamic Therapy. (3) The microsystem can potentially realize clinically-proven superadditive anticancer effect – stronger than any single therapy or theoretical combination. The microsystem-mediated multimodal cancer therapy would be validated through a comprehensive evaluation by employing clinically relevant models (in vitro and in vivo cancer models). The outcome of this project justifies the development of the IMD-mediated multimodal cancer therapy that will potentially help patients suffering from aggressive and fatal cancer types with limited treatment alternatives.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该职业项目是全球攻克癌症这一第二大死因的努力的一部分。尽管在研究和开发方面投入巨大，但作为一种可行的癌症疗法，临床上却很少取得成功。癌症治疗的最新进展导致植入式医疗设备 (IMD) 成为可行的药物，因为它们具有局部治疗的能力，尽管数量有限。然而，目前可用的 IMD 介导的癌症治疗通常仅限于每次治疗一次、不可补充的给药。这些限制以及许多风险，例如痛苦的手术、导管感染风险和装置故障，通常阻碍了 IMD 在癌症治疗中的使用。更重要的是，由于癌症的复杂性、多样性和异质性，无法用单一的治疗方法有效治疗。因此，这个 CAREER 项目研究了一种以声学驱动的可植入微系统形式存在的多功能工程解决方案，该系统提供了多模式癌症治疗的定制组合：氧气、化疗药物和光。该项目旨在建立“声生物电子学”领域，激发对下一代 IMD 的新理论和理解。此外，该项目通过指导研究生和本科生将研究与教育场所结合起来，特别注重代表性不足的少数族裔和女学生，开发跨学科课程，并创建从基础理论到实践活动的教学资源。虽然IMD正在改变现代医疗保健，但由于其寿命较短，目前无法治愈癌症。许多癌症可能复发或转移性扩散，这一事实使情况变得更加复杂。该 CAREER 项目的总体目标是利用工程和医疗保健领域的跨领域创新来创建超声波驱动的可植入微系统，从而实现多模式癌症疗法的定制组合。这项研究 (1) 利用独特的可 3D 打印钛酸钡超声波接收器，阐明了柏拉图式固体结构在 IMD 高效全向超声波供电方案中尚未开发的潜力。 (2) 通过超声波提供足够的能量，该微系统能够通过受控的电化学和光化学过程原位产生氧气、顺铂和光。因此，它被称为氧气增强化学光动力疗法。 (3) 该微系统有可能实现临床证明的超累加抗癌效果——比任何单一疗法或理论组合更强。微系统介导的多模式癌症治疗将通过采用临床相关模型（体外和体内癌症模型）的综合评估来验证。该项目的结果证明了 IMD 介导的多模式癌症疗法的开发是合理的，该疗法将有可能帮助患有侵袭性和致命性癌症类型且治疗方案有限的患者。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Multifunctional 3D printed BaTiO3 platonic solids packaging for implantable microdevices

用于植入式微型设备的多功能 3D 打印 BaTiO3 柏拉图式固体封装

• 发表时间: 2022
• 期刊: Actuators and Microsystems Workshop
• 作者: Albert Kim Sayemul Islam, Sumnoon Ahmed

Protein redox by a piezoelectric acousto-nanodevice

压电声纳米装置的蛋白质氧化还原

• DOI: 10.1039/d3nr01523h
• 发表时间: 2023
• 期刊: Nanoscale
• 影响因子: 6.7
• 作者: Selvarajan, Sophia;Shim, Hyunji;Byun, Eunjeong;Kim, Albert;Song, Seung Hyun
• 通讯作者: Song, Seung Hyun

Totally Implantable Oxygen Generator (TIOG) for Hypoxia and Hypoxemia

• DOI: 10.1109/tbme.2022.3217164
• 发表时间: 2023-04-01
• 期刊: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
• 影响因子: 4.6
• 作者: Islam，Sayemul;Huggins，Rebecca C.;Kim，Albert
• 通讯作者: Kim，Albert