2D polarization resolved optical spectroscopy for exploration of conformation, energy transfer and aggregation of macromolecules (conjugated polymers and proteins) within different environments under the goal to contribute to the improvement of organic bu

这个项目将使用最近发展起来的2D偏振成像技术(2D POLIM)来探索大分子的构象和聚集。这项研究的目的是对所研究的大分子的组织结构建立新的见解，并展望其在有机电子中的改进应用。一方面，研究对象将是共轭聚合物，由于其电学和光学性质，它适合用于有机电子学。将2D POLIM应用于共轭聚合物在液晶(LC)基质中的稀释溶液，将使我们能够评估聚合物链/粒子的拓扑结构，并测量这些对象内部的能量转移程度。与无定形聚合物基质相比，液晶提供了一种已知的局域结构，可以通过温度和电场来控制。在链大小、链构象、聚集度和能量转移效率之间建立明确的关联仍然缺乏。这些知识对有机电子学尤其重要，因为高分子链的形态似乎是影响器件性能的关键。另一方面，对活细胞和体外生物聚合物的研究有望为其功能和组织的复杂途径提供新的见解。功能结构在细胞生物学中扮演着重要的角色。通过将我们的研究活动扩展到生物材料的研究，我们希望为有机太阳能电池的改进找到可行的线索。初步研究证明，2D POLIM在生物医学样品中解析结构的能力优于传统的荧光光谱技术。隆德大学将与生物医学中心瓦伦堡神经科学中心合作，探索蛋白质中的聚集态。与其他荧光显微技术相比，2D POLIM能够解决能量转移和粒子取向问题，为研究蛋白质之间的相互作用提供了一种更直接的途径。通过对这两种材料的研究，我们期待着为有机体异质结太阳能电池的改进提供新的视角。已经存在的与瑞典有机电子中心(COE)的合作将为我们提供材料，以直接测试我们的研究结果所激发的结构和材料组成。

This project will explore conformation and aggregation of macromolecules using recently developed 2D polarization imaging techniques (2D POLIM). The aim of the investigation is to establish new insight into the organization of the studied macromolecules with the prospect for improved applications in organic electronics. The studied objects, one the one hand, will be conjugated polymers, which due to their electronic and optical properties are suitable for organic electronics. Application of 2D POLIM to diluted solutions of conjugated polymers in liquid crystal (LC) matrices will enable us to evaluate the topology of the polymer chains/particles and measure the extend of energy transfer within these objects. In contrast to amorphous polymer matrices, LCs provide a known local structure, which can be controlled by temperature and electric field. Establishing of unambiguous correlations between the chain size, chain conformation, degree of aggregation and energy transfer efficiency is still lacking. Such knowledge is especially important for organic electronics where the polymer chain morphology seems to be the key for the device performance. On the other hand, investigation of biopolymers in living cells and in vitro is expected to provide new insight in the complex pathways of their functionality and organization. Functional structures play a prominent role in cell biology. By extending our research activities to the investigation of biological materials, we expect to find viable clues for the improvement of organic solar cells. Preliminary investigation proved the power of 2D POLIM to resolve structures in biomedical samples to be superior to conventional fluorescence spectroscopy techniques. In cooperation with the Wallenberg Neuroscience Center, Bio-Medical Center, Lund University aggregation states in proteins will be explored. The ability of 2D POLIM to resolve energy transfer together with particle orientations, provides a more direct approach on interaction of proteins than other fluorescence microscopy techniques.From the investigations of both materials, we expect new insight for the improvement of organic bulk heterojunction solar cells. The already existing collaboration with the Swedish Center for Organic Electronics (COE) will provide us with materials to directly test structures and material compositions motivated by the results from our studies.