Cognitive remediation therapy for patients with depression

抑郁症患者的认知矫正治疗

• 批准号: 256846284
• 负责人: Professorin Dr. Daniela Roesch-Ely
• 金额: --
• 依托单位: Klinik für Allgemeine Psychiatrie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/256846284?language=en
• 关键词: Cognitive; remediation; therapy; patients; depression

Depression is one of the major causes of long-term disability at a high cost for the individual patient and society. Beside illness severity itself, cognitive impairment plays a critical role for general functioning in major depression as it may persist even after remission of other psychopathological symptoms. Therefore, Cognitive Remediation Therapy (CRT) is increasingly discussed as an important therapeutic intervention for depressed patients. Up to now, only few empirical studies investigated the usefulness of cognitive remediation in MDD patients with persistent cognitive deficits. For this reason, the main goal of this study is to examine the effectiveness of cognitive training in those MDD patients who suffer from cognitive deficits despite remission of acute depressive symptoms. It is expected that cognitive training significantly improves neuropsychological functioning in comparison to the passive control condition. Furthermore, for psychiatric patients in general the existing positive findings of CRT stem from a wide array of different training designs, which render the optimal design a matter of considerable debate. Several authors have emphasized the need to individualize CRT in order to increase effects on cognition, motivation and transfer to real-world situations. This approach contrasts with generic training programs, which target a broad set of functions. However, no direct comparison between individualized and generic training programs has been conducted so far. Therefore, in the present study, both an individualized as well as a generalized training approach will be used and compared on an exploratory level. Long term effects of the intervention at 6-month follow-up as well as effects on psychosocial functioning will also be investigated on an exploratory level.Moreover, a combined resting-state and task-based functional magnetic resonance imaging protocol will be employed to investigate treatment-related adaptive changes of neural function in patients. Both regional specific brain activation changes and changes of functional network connectivity will be investigated.

抑郁症是导致长期残疾的主要原因之一，给患者个人和社会带来高昂的代价。除了疾病严重程度本身之外，认知障碍对于重度抑郁症的一般功能也起着至关重要的作用，因为即使在其他精神病理症状缓解后，认知障碍也可能持续存在。因此，认知矫正疗法（CRT）越来越多地被讨论为抑郁症患者的重要治疗干预措施。到目前为止，只有少数实证研究调查了认知矫正对患有持续性认知缺陷的重度抑郁症患者的有效性。因此，本研究的主要目标是检查认知训练对那些尽管急性抑郁症状缓解但仍患有认知缺陷的重度抑郁症患者的有效性。与被动控制条件相比，预计认知训练可显着改善神经心理功能。此外，对于一般精神病患者来说，CRT 现有的积极结果源​​于各种不同的训练设计，这使得最佳设计成为一个相当大的争论。几位作者强调需要个性化 CRT，以增强对认知、动机和转移到现实世界情境的影响。这种方法与针对广泛职能的通用培训​​计划形成鲜明对比。然而，到目前为止，还没有对个性化培训计划和通用培训计划进行直接比较。因此，在本研究中，将使用个体化和通用的培训方法并在探索性水平上进行比较。还将在探索性水平上研究干预在 6 个月随访中的长期影响以及对心理社会功能的影响。此外，将采用组合静息态和基于任务的功能磁共振成像方案来研究患者神经功能与治疗相关的适应性变化。将研究区域特定的大脑激活变化和功能网络连接的变化。

项目成果

Kognitive Defizite bei Depressionen und ihre Behandlung

抑郁症的认知缺陷及其治疗

• DOI: 10.1055/s-0041-100096
• 发表时间: 2015
• 期刊: PSYCH up2date
• 作者: Roesch-Ely;Weisbrod;Bartolovic
• 通讯作者: Bartolovic

Serum calcium levels and neuropsychological performance in depression and matched healthy controls: Reversal of correlation a marker of the aging cognitive clock?

• DOI: 10.1016/j.psyneuen.2018.03.012
• 发表时间: 2018-05-01
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Gruetzner, Thea Marianne;Listunova, Lena;Sharma, Anuradha
• 通讯作者: Sharma, Anuradha

Neurocognitive performance in patients with depression compared to healthy controls: Association of clinical variables and remission state

• DOI: 10.1016/j.psychres.2018.11.047
• 发表时间: 2019-01
• 期刊: Psychiatry Research
• 影响因子: 11.3
• 作者: Thea Marianne Grützner;Anuradha Sharma;Lena Listunova;M. Bartolovic;M. Weisbrod;D. Roesch-Ely