Accelerating Cognitive Gains from Digital Meditation with Noninvasive Brain Stimulation: A Pilot Study in MCI

通过无创大脑刺激加速数字冥想的认知收益：MCI 的初步研究

• 批准号: 10584429
• 负责人: THEODORE P ZANTO
• 金额: $ 52.45万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10584429
• 关键词: Acceleration; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Attention; Biological Markers; Blood; Cephalic; Clinical Markers; Cognition; Cognitive; Cognitive deficits; Cognitive remediation; Combined Modality Therapy; Coupling; Data; Dementia; Elderly; Exhibits; Forehead; Foundations; Frequencies; Future; Goals; Home; Impaired cognition; Intervention; Length; Meditation; Monitor; Outcome Measure; Participant; Patients; Performance; Personal Satisfaction; Physiological; Pilot Projects; Placebos; Population; Prefrontal Cortex; Randomized, Controlled Trials; Reaction Time; Regulation; Research; Sleep; Stress; Subgroup; Testing; Therapeutic; Time; Training; attentional control; cognitive ability; cognitive enhancement; cognitive reserve; cognitive task; dementia risk; digital; efficacy evaluation; examination questions; functional decline; group intervention; high risk; improved; improvement on sleep; indexing; mild cognitive impairment; neural stimulation; neuropathology; noninvasive brain stimulation; normal aging; novel; pre-clinical; prevent; progression risk; remediation; stress reactivity; stress reduction; sustained attention; telomere; tool; wearable sensor technology; young adult

Abstract The overall goal of this project is to collect pilot feasibility and early efficacy data showing improvements in cognition and wellbeing in adults with mild cognitive impairment (MCI) through a combination treatment of non-invasive brain stimulation (transcranial alternating current stimulation (tACS)) and a novel form of closed-loop digital meditation (Meditrain). MCI is a transitional stage between normal aging and dementia, and patients with MCI are at high risk of progressing onto Alzheimer’s disease and other dementias. Non-invasive brain stimulation and focused-attention meditation are two approaches that hold great promise for boosting cognitive abilities and enhancing wellbeing in OA at risk of Alzheimer’s disease. While a handful of studies have combined neural stimulation with meditation in healthy young adults, none have employed digital closed loop meditation nor examined this question in a population at high risk of Alzheimer’s disease. Thus, the goal of this proposed research is to collect pilot data to test the hypothesis that coupling MediTrain with frequency-specific (i.e., theta) tACS targeting frontal attention networks will lead to faster and/or greater magnitude of gains in cognitive abilities, real-world indices of stress and sleep, and key blood biomarkers of aging in aMCI patients. To accomplish these aims, we will conduction an RCT on 90 OA with aMCI who will be assigned to one of three intervention groups: MediTrain + 6Hz tACS (n = 30), MediTrain + sham tACS (n = 30), or a placebo (Worder app + sham tACS) intervention (n = 30). Theta (6Hz) or sham (i.e., none) stimulation will be applied to the forehead using Humm patches during 30min of training in participants’ homes, 4 days per week, for 4 weeks. Outcome measures will consist of cognitive/attention tasks, physiological indices of sleep and stress (both in lab and at home via wearable sensors), and blood biomarkers of aging (telomere length). This research will provide an important contribution toward understanding the combination of tACS and meditation as a therapeutic tool for bolstering cognitive reserve and increasing overall wellbeing in patients with MCI.

摘要 本项目的总体目标是收集试点可行性和早期疗效数据，以显示改善情况 在轻度认知障碍（MCI）成人中， 治疗非侵入性脑刺激（经颅交流电刺激（tACS））和 闭环数字冥想（Meditrain）的新形式。MCI是一个过渡阶段， 老年痴呆症，MCI患者进展为阿尔茨海默病的风险很高 和其他痴呆症。非侵入性脑刺激和集中注意力冥想是两个 这些方法对于提高OA的认知能力和改善OA的福祉具有巨大的希望， 阿尔茨海默病的风险。虽然少数研究将神经刺激与冥想结合起来， 在健康的年轻人中，没有人使用过数字闭环冥想，也没有人研究过这个问题。 在阿尔茨海默病高危人群中。因此，本研究的目的是收集 试验数据以测试将MediTrain与频率特异性（即，θ）tACS 瞄准正面注意力网络将导致认知能力更快和/或更大幅度的提高， 能力，压力和睡眠的真实世界指数，以及aMCI患者衰老的关键血液生物标志物。到 为了实现这些目标，我们将对90名患有aMCI的OA患者进行RCT，这些患者将被分配到 三个干预组：MediTrain +6 Hz tACS（n = 30），MediTrain +假tACS（n = 30），或 安慰剂（Worder app +假tACS）干预（n = 30）。Theta（6 Hz）或假动作（即，无）刺激 将在参与者家中进行30分钟的培训期间使用Humm贴片贴在前额，4 每周7天，持续4周。结果测量将包括认知/注意力任务、生理学和心理学。 睡眠和压力指数（通过可穿戴传感器在实验室和家中），以及 老化（端粒长度）。这项研究将为了解 结合tACS和冥想作为一种治疗工具，用于增强认知储备和提高 MCI患者的总体健康状况。