I-Corps: Biosensor for landmine detection

I-Corps：用于地雷探测的生物传感器

• 批准号: 2322309
• 负责人: Chang-Hui Shen
• 金额: $ 5万
• 依托单位: CUNY College of Staten Island
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2024-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2322309&HistoricalAwards=false
• 关键词: Corps; Biosensor; landmine; detection

The broader impact/commercial potential of this I-Corps project is the development of a next-generation landmine detection biosensor that can be distributed in a wide range of fields, in various environmental conditions. The project's primary goal is to provide a safe and efficient method to detect landmines, which are often buried and camouflaged, causing a significant threat to both military forces and civilians. The current detection methods are outdated and risky, requiring physical on-site presence, and they are also costly. Therefore, the proposed project aims to provide a more efficient and cost-effective solution by utilizing genetic engineering, microbiology, and biochemical approaches. The innovative biosensor system will employ two biosensors that are engineered to use TNT/DNT and toluene as the sole nitrogen-source and carbon source, respectively, to detect landmines and generate fluorescent signals that can be amplified several folds for easy detection.This I-Corps project is based on the development of a highly sensitive landmine detection biosensor. The proposed biosensor will employ bioreporter, genetic engineering, microbiology, and biochemical approaches. The key features of this technology include (1) signal amplification, (2) extreme environment adaptation, and (3) TNT/DNT-response. The project's potential benefits extend beyond landmine detection and clearance, as it can enhance our understanding of bio- and nano-technology in explosive detection. It can also contribute to socioeconomic development by providing a cost-effective solution for detecting landmines globally, where there are currently an estimated 100 million landmines in the ground, and mine action costs exceed $500 million annually. Therefore, this innovative landmine biosensor system can potentially reduce the morbidity and mortality caused by the buried landmines and promote socioeconomic development in affected regions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

I-Corps项目更广泛的影响/商业潜力是开发下一代地雷检测生物传感器，该传感器可以分布在各种环境条件下的广泛领域。该项目的主要目标是提供一种安全有效的方法来探测地雷，地雷往往被掩埋和伪装，对军队和平民都构成重大威胁。目前的检测方法既过时又有风险，需要亲自到场，而且成本也很高。因此，拟议的项目旨在通过利用基因工程、微生物学和生化方法提供更有效和更具成本效益的解决方案。创新的生物传感器系统将采用两个生物传感器，分别使用TNT/DNT和甲苯作为唯一的氮源和碳源来探测地雷，并产生可放大数倍的荧光信号以便于探测。这个i-Corps项目是基于开发一种高灵敏度的地雷探测生物传感器。建议的生物传感器将采用生物报告、基因工程、微生物学和生化方法。该技术的主要特点包括(1)信号放大，(2)对极端环境的适应，(3)TNT/DNT响应。该项目的潜在好处不仅仅是地雷探测和清除，因为它可以增进我们对爆炸物探测中的生物和纳米技术的了解。它还可以为全球地雷探测提供具有成本效益的解决办法，从而促进社会经济发展。目前，全球地下估计有1亿枚地雷，排雷行动每年的费用超过5亿美元。因此，这一创新的地雷生物传感器系统可以潜在地降低埋在地下的地雷造成的发病率和死亡率，并促进受影响地区的社会经济发展。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。