I-Corps: Novel hydrogels for chronic diseases in pets and livestock

I-Corps：治疗宠物和牲畜慢性疾病的新型水凝胶

• 批准号: 2327750
• 负责人: Krzysztof Marycz
• 金额: $ 5万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2327750&HistoricalAwards=false
• 关键词: Corps; Novel; hydrogels; chronic; diseases

The broader impact potential of this I-Corps project is a novel approach for the treatment of oral inflammatory and ulcerative diseases in dogs and cats. As the biggest challenge with inflammatory dental disease treatment lies in biofilm reduction, anti-viral mechanisms, immune system modulation, and reduction of inflammation, our solution tackles it all with economically feasible, easy to use, and efficient technology. This innovation will stimulate stem cells to grow and promote wound healing of damaged tissue by maintaining gingival mesenchymal stem cells homeostasis. This novel approach for Feline chronic gingivostomatitis treatment with the application of Lactic Acid Bacteria-derived metabolites and exosomes combined with organic zinc nanoparticles and hydrogel in a formulation.This I-Corps project is based on the development of treatment of periodontal disease, which is the most common infectious condition in adult dogs and cats. It is a progressive, cyclical inflammatory disease of the supporting structures of the tooth and is the main cause of dental disease and early tooth loss in both species. It affects over 87% of dogs and 70% of cats over three years of age. This novel approach uses a hydrogel enriched with paraprobiotics (non-infectious microbial cell components such as peptidoglycans, teichoic acids, surface proteins, etc.) and lactic acid bacteria probiotics derived biomolecules, so-called postbiotics (exosomes, enzymes, secreted proteins, short chain fatty acids, vitamins, secreted biosurfactants, amino acids, peptides, organic acids, etc.) enhanced with biologically produced zinc oxide nanoparticles. This technology will help cats by reducing inflammation, dental plaque, chronic pain, promoting tissue and cell regeneration, treating viral infection, and improving wound healing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响潜力是一种治疗犬和猫口腔炎症和溃疡性疾病的新方法。由于炎症性牙病治疗的最大挑战在于生物膜减少、抗病毒机制、免疫系统调节和炎症减少，我们的解决方案通过经济可行、易于使用和高效的技术解决了这一切。这项创新将刺激干细胞生长，并通过维持牙龈间充质干细胞的体内平衡来促进受损组织的伤口愈合。这种新的方法用于猫慢性牙龈口炎的治疗与应用乳酸菌衍生的代谢产物和外泌体结合有机锌纳米颗粒和水凝胶的配方。这个I-Corps项目是基于牙周病治疗的发展，这是成年狗和猫最常见的感染性疾病。它是牙齿支撑结构的进行性、周期性炎症性疾病，是两个物种中牙齿疾病和早期牙齿脱落的主要原因。它影响了超过87%的狗和70%的猫超过三岁。这种新方法使用富含副益生菌（非感染性微生物细胞组分，如肽聚糖、磷壁酸、表面蛋白等）的水凝胶。和乳酸菌益生菌衍生的生物分子，即所谓的益生菌后体（外泌体、酶、分泌蛋白、短链脂肪酸、维生素、分泌生物表面活性剂、氨基酸、肽、有机酸等）。用生物产生的氧化锌纳米颗粒增强。这项技术将通过减少炎症、牙菌斑、慢性疼痛、促进组织和细胞再生、治疗病毒感染以及改善伤口愈合来帮助猫。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。