Proto-OKN Theme 1: A Dynamically-Updated Open Knowledge Network for Health: Integrating Biomedical Insights with Social Determinants of Health

该项目旨在通过纳入健康的社会决定因素（SDoH）数据来扩大目前的生物医学知识图谱，尽管这些数据已被证明与健康结果有关，但通常未得到充分利用。目标是创建一个综合的健康知识图谱，结合生物医学事实和来自科学文献和电子健康记录的SDoH数据。至关重要的是，这种模式将允许不断更新正在进行的生物医学和临床文本数据流，促进新研究成果的快速分发，并促进不断发展的生物医学和公共卫生领域的合作。组织、分析和应用生物医学信息的生物医学知识图谱（KGs）很少纳入与社会经济地位、教育和就业等非临床因素相关的数据，而这些因素已被证明与几种健康结果相关。至关重要的是，要将SDoH集成到开放知识库中，以加强健康改善工作，并减少医疗保健资源可及性方面的持续差异。这一整合的一个结果将是一个综合的卫生知识网络，将生物医学事实与SDoH数据结合起来。这个网络可以不断地用新数据自我更新。这一努力面临的挑战包括数据集成、数据流的动态性，以及以公平和合乎道德的方式将生物医学知识与SDoH数据结合起来的需要。为了应对这些挑战，该项目将创建一个多维知识网络，能够支持跨各种应用程序的复杂查询，并自动验证信息质量。该项目还将把这些指标与电子健康记录联系起来，以揭示社会决定因素与健康结果之间的联系，从而改善保健结果并促进健康公平。该项目通过推进语义互操作性、改进知识表示、实现自适应知识获取、确保知识图可信度和促进道德意识进行创新。它旨在生成一个综合的知识网络、开源算法、模型和工具，以集成SDoH事实和数据。本项目创建的工具的可获得性将加速知识发现，提高对人类健康和弱势群体福祉的了解。此外，该项目将通过特别研讨会课程和正在进行的多样性倡议，为学生，特别是来自代表性不足群体的学生的教育作出重大贡献。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This project aims to expand current biomedical knowledge graphs by incorporating Social Determinants of Health (SDoH) data, which are typically underutilized despite their proven connection to health outcomes. The goal is to create a comprehensive health knowledge graph that combines biomedical facts and SDoH data from scientific literature and Electronic Health Records. Crucially, this model will allow for continuous updates from ongoing streams of biomedical and clinical text data, promoting swift distribution of new research findings and fostering collaboration in the ever-evolving biomedical and public health fields. Biomedical knowledge graphs (KGs), which organize, analyze, and apply biomedical information, rarely incorporate data related to non-clinical factors like socioeconomic status, education, and employment, that have proven correlations with several health outcomes. It is crucial to integrate SDoH into open knowledge repositories to enhance health improvement efforts and to reduce persistent disparities in healthcare resource accessibility. One outcome of this integration would be a comprehensive knowledge network for health that merges biomedical facts with SDoH data. This network could continually update itself with new data. Challenges to this endeavor include data integration, the dynamic nature of data streams, and the need to combine biomedical knowledge with SDoH data in an equitable and ethical manner. To address these challenges, the project will create a multi-dimensional knowledge network capable of supporting complex queries across various applications and automatically verifying information quality. The project will also link the KGs with electronic health records to uncover associations between social determinants and health outcomes, thereby improving healthcare outcomes and promoting health equity. This project innovates by advancing semantic interoperability, improving knowledge representation, enabling adaptive knowledge acquisition, ensuring knowledge graph trustworthiness, and promoting ethical awareness. It aims to yield a comprehensive knowledge network, open-source algorithms, models, and tools that integrate SDoH facts and data. The accessibility of the tools created in this project will accelerate knowledge discovery, improving the understanding of human health and the wellbeing of vulnerable populations. Additionally, this project will significantly contribute to the education of students, particularly those from underrepresented groups, through special seminar courses and ongoing diversity initiatives.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.