Conference: DMR-NIBIB Planning Workshop: Leveraging data-driven design and synthetic biology to enable next-generation active biomaterials

摘要：作为美国国家科学基金会材料研究部（DMR）和美国国家生物医学成像和生物工程研究所（NIBIB）新合作的一部分，该奖项将支持俄勒冈大学的一个计划研讨会，题为“利用数据驱动设计和合成生物学来实现下一代活性生物材料”。生物材料已经从“现成的”材料发展到与生物系统（如人体）积极相互作用的材料。这种“下一代”生物材料具有可调的特性，可用于许多生物应用，包括组织工程、综合生物学和药物输送。这些科学贡献在促进生物学和人类健康方面显示出巨大的希望；然而，在将这些令人兴奋的材料科学进展转化为针对紧迫的生物医学问题的可行方法方面，还存在一个主要差距。本次研讨会将是一个论坛，以突出和探索该领域的最新发展，并促进多学科计划的发展，以弥合临床翻译的差距。本次研讨会将重点讨论开发和翻译下一代生物材料所必需的4个主题：生物材料设计的数据驱动方法，合成生物学支持的生物材料，智能/响应生物材料，以及生物制造和生物界面。研讨会的目标是：1 .展示下一代生物材料的最新进展；2。促进聚合物科学家、化学家、生物工程师和生物学家之间的对话，以进一步设计和应用生物材料，并弥合临床翻译的差距；ⅲ。拓宽(1)生物材料研究的范围，以匹配患者群体（种族、性别等）的多样性；(2)参与者，特别是来自历史上被边缘化的群体，以推动生物材料研究的创造性和独特方法。技术摘要：该奖项将支持俄勒冈大学的一个计划研讨会，题为“利用数据驱动设计和合成生物学来实现下一代活性生物材料”，这是美国国家科学基金会材料研究部（DMR）和美国国家生物医学成像和生物工程研究所（NIBIB）之间新合作的一部分。生物材料已经从植入的“现成”材料发展到合理设计的材料，这些材料可以与生物系统相互作用并指导生物系统实现预期的生物结果。这种“下一代”生物材料目前正在开发中，以满足对多种生物应用（包括组织工程、综合生物学和药物输送）的定制和可调性能材料日益增长的需求。这些科学贡献在推进众多基于生物材料的应用方面显示出巨大的希望。然而，将这些令人兴奋的材料科学进展转化为针对紧迫的生物医学问题的可行方法，包括在损伤/疾病后实现强大的组织再生，调整局部和按需药物输送，以及实现实时生物传感，这方面存在重大差距。本次研讨会将是一个论坛，以突出和探索该领域的最新发展，并促进多学科计划的发展，以弥合临床翻译的差距。本次研讨会将重点关注开发和翻译下一代生物材料所必需的4个综合科学驱动因素：生物材料设计的数据驱动方法，合成生物学支持的生物材料，智能/响应生物材料，以及生物制造和生物界面。研讨会的目标是：1 .展示下一代生物材料的各种科学驱动主题的最新进展；2。促进聚合物科学家、化学家、生物工程师和生物学家之间的对话，以进一步设计和应用生物材料，并制定多学科计划，以弥合翻译的差距；ⅲ。拓宽(1)翻译生物材料的应用范围，以匹配患者群体（种族，性别等）的多样性；(2)参与者，特别是来自历史上被边缘化的群体，以推动创造性和独特的方法。强调来自不同背景的跨学科研究人员的进步对于提供这些前瞻性研究途径的核心至关重要。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Non-technical Abstract:This award will support a planning workshop at the University of Oregon entitled “Leveraging data-driven design and synthetic biology to enable next-generation active biomaterials” as part of a new collaboration between the National Science Foundation’s Division of Materials Research (DMR) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Biomaterials have evolved from ‘off the shelf’ materials to materials that actively interact with biological systems such as the human body. This “next generation” of biomaterials have tunable properties for numerous biological applications, including tissue engineering, integrative biology, and drug delivery. These scientific contributions have shown great promise in advancing biology and human health; however, a major gap exists in converting these exciting advances in materials science into feasible approaches tailored toward pressing biomedical problems. This workshop will be a forum to highlight and explore the recent developments in the field and facilitate the development of a multidisciplinary plan to bridge the gap to clinical translation. This workshop will focus on 4 topics integral to developing and translating next-generation biomaterials: data-driven methods for biomaterials design, synthetic biology-enabled biomaterials, smart/responsive biomaterials, and biofabrication and biointerfaces. The objectives of the workshop are to: I. Showcase recent advances in the next generation biomaterials; II. Facilitate a dialogue between polymer scientists, chemists, bioengineers, and biologists to further the design and application of biomaterials and to bridge the gap to clinical translation; and III. Broaden the (1) scope of biomaterials research to match the diversity of patient populations (ethnicity, gender, etc.) and (2) participants, especially from historically marginalized groups, to drive creative and unique approaches to biomaterials research.Technical Abstract:This award will support a planning workshop at the University of Oregon entitled “Leveraging data-driven design and synthetic biology to enable next-generation active biomaterials” as part of a new collaboration between the National Science Foundation’s Division of Materials Research (DMR) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Biomaterials have evolved from implanted ‘off the shelf’ materials to rationally designed materials that interact with and instruct biological systems to achieve desired biological outcomes. This “next generation” of biomaterials are currently being developed to meet the growing demand for materials with tailored and tunable properties for numerous biological applications, including tissue engineering, integrative biology, and drug delivery. These scientific contributions have shown great promise in advancing numerous biomaterials-based applications. However, a major gap exists in converting these exciting advances in materials science to feasible approaches tailored toward pressing biomedical problems, including achieving robust tissue regeneration after injury/disease, tuning localized and on-demand drug delivery, and enabling real-time biosensing. This workshop will be a forum to highlight and explore the recent developments in the field and facilitate the development of a multidisciplinary plan to bridge the gap to clinical translation. This workshop will focus on 4 integrated science drivers integral to developing and translating next-generation biomaterials: data-driven methods for biomaterials design, synthetic biology-enabled biomaterials, smart/responsive biomaterials, and biofabrication and biointerfaces. The objectives of the workshop are to: I. Showcase recent advances in the various science drivers’ topics of next-generation biomaterials; II. Facilitate a dialogue between polymer scientists, chemists, bioengineers, and biologists to further the design and application of biomaterials and develop a multidisciplinary plan to bridge the gap to translation; and III. Broaden the (1) scope of applications of translational biomaterials to match the diversity of patient populations (ethnicity, gender, etc.) and (2) participants, especially from historically marginalized groups, to drive creative and unique approaches. Highlighting the advances of interdisciplinary investigators from diverse backgrounds is vital to providing nucleation of these forward-looking research avenues.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.