CAREER: Multisensory Soft Bioelectronics for Comprehensive Monitoring of Gastrointestinal Physiological Interplay

职业：用于全面监测胃肠道生理相互作用的多感官软生物电子学

• 批准号: 2339495
• 负责人: Jinxing Li
• 金额: $ 50万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-05-01 至 2029-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2339495&HistoricalAwards=false
• 关键词: CAREER; Multisensory; Soft; Bioelectronics; Comprehensive

The gut, or gastrointestinal tract, widely regarded as our “second brain,” represents the body’s most sophisticated physiological system with complicated biochemistry and biomechanics: (1) Gut biochemistry: it is the home to trillions of microbes that not only transform the diet into key nutrients but also release a variety of neurotransmitters (such as serotonin) and hormones, exerting a marked influence on our physical and mental health. (2) Gut biomechanics: it has multiple muscle layers that stretch and contract synchronously to produce a diverse gut motility pattern for digestion and nutrition absorption. The complex interplay between the gut’s biochemistry and biomechanics constitutes the fundamental physiology of the gastrointestinal system. Dysregulation of these processes can lead to diverse neurological, immune, and bowel disorders. However, studying the complicated physiological inter-regulation in such a series of soft, stretchy, long, and twisting organs with a variety of motility patterns has been a long-standing challenge due to the mechanical mismatch between the biological tissue and conventional electronic components. This project seeks to fill this critical technology gap by developing a soft multisensory bioelectronic device that provides robust and intimate tissue coupling while maintaining its biochemical and biomechanical sensing function during continuous gut motion. The outcomes will be new biodata to spur our fundamental understanding of gut physiology, the interplay between serotonin dynamics and gut motility, as well as new bioelectric tools to diagnose and treat digestive and neurological disorders. This project aims to broaden the participation of young people in engineering, with a particular emphasis on underrepresented minorities and female students. This will be achieved through a comprehensive education plan with a variety of engaging activities, including K-12 student and teacher summer programs on electronics and robotics, undergraduate research programs and design-focused courses, and science and art festival demonstrations.This CAREER proposal aims to integrate unconventional electronic materials and device design, innovative microfabrication methods, wireless hardware, and computational methods, to develop a new type of high-performance multisensory soft bioelectronics capable of simultaneously monitoring gut biochemical release and physical motion with minimized perturbation to the biological system. The proposed multisensory bioelectronic device, with the goal of decoding the gut serotonin and motility interplay, will integrate: (1) A new soft biosensor array for high-resolution gut serotonin detection and mapping, (2) A new soft physical sensor array for high-performance gut motility monitoring, and (3) An implantable wireless integrated circuit for data recording and transmission in freely moving animals and computational methods for the newly produced biodata analysis. With multimodal sensing and mechanical softness, the resulting bioelectronic device will provide robust and intimate tissue coupling while maintaining its high-performance biochemical and biomechanical sensing function during continuous gut motion at its natural state. In the long term, the new bioelectronic tool described here will not only generate new knowledge in electrical materials and biosensing but also provide new insights into studying gut physiology and microbiota–gut–brain communication, potentially leading to new tools to diagnose and treat various neurological and digestive diseases.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

肠道被广泛认为是我们的“第二大脑”，代表了人体最复杂的生理系统，具有复杂的生物化学和生物力学：（1）肠道生物化学：它是数以万亿计的微生物的家园，这些微生物不仅将饮食转化为关键的营养物质，还释放出各种神经递质（如血清素）和激素，对我们的身心健康产生显着影响。(2)肠道生物力学：它具有多个肌肉层，这些肌肉层同步地伸展和收缩以产生用于消化和营养吸收的不同的肠道运动模式。肠道生物化学和生物力学之间复杂的相互作用构成了胃肠系统的基本生理学。这些过程的失调可导致各种神经、免疫和肠道疾病。然而，由于生物组织和传统电子元件之间的机械失配，研究这样一系列具有各种运动模式的柔软、有弹性、长且扭曲的器官中复杂的生理相互调节一直是一个长期存在的挑战。该项目旨在通过开发一种柔软的多传感生物电子设备来填补这一关键技术空白，该设备提供强大而紧密的组织耦合，同时在连续肠道运动期间保持其生化和生物力学传感功能。这些成果将是新的生物数据，以刺激我们对肠道生理学的基本理解，血清素动力学和肠道运动之间的相互作用，以及诊断和治疗消化和神经系统疾病的新生物电工具。该项目旨在扩大年轻人对工程学的参与，特别强调代表性不足的少数民族和女学生。这将通过一个全面的教育计划与各种吸引人的活动来实现，包括K-12学生和教师关于电子和机器人的暑期课程，本科生研究项目和以设计为重点的课程，以及科学和艺术节演示。这个CAREER提案旨在整合非传统的电子材料和设备设计，创新的微制造方法，无线硬件和计算方法，开发一种新型的高性能多传感器软生物电子学，能够同时监测肠道生化释放和物理运动，同时最大限度地减少对生物系统的干扰。所提出的多传感器生物电子设备，以解码肠道血清素和运动相互作用为目标，将整合：（1）用于高分辨率肠道血清素检测和绘图的新型软生物传感器阵列，（2）用于高性能肠道运动监测的新型软物理传感器阵列，以及（3）一种用于自由活动动物数据记录和传输的可植入无线集成电路以及新产生生物数据的计算方法分析.通过多模态感测和机械柔软性，所产生的生物电子设备将提供稳健和紧密的组织耦合，同时在其自然状态下的连续肠道运动期间保持其高性能的生化和生物力学感测功能。 从长远来看，这里描述的新生物电子工具不仅将产生电学材料和生物传感方面的新知识，还将为研究肠道生理学和微生物-肠道-大脑通信提供新的见解，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准。