Woods Hole Center for Oceans and Human Health

伍兹霍尔海洋与人类健康中心

• 批准号: 2418297
• 负责人: Dennis McGillicuddy
• 金额: $ 439.64万
• 依托单位: Woods Hole Oceanographic Institution
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-04-15 至 2029-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2418297&HistoricalAwards=false
• 关键词: Woods; Hole; Center; Oceans; Human

The Woods Hole Center for Oceans and Human Health is a five-year effort aimed at addressing how changing climate could influence harmful algal bloom (HAB) dynamics and human exposure to HAB toxins, a serious and global human health threat. The overall objective is to protect public health through enhanced understanding of how climate and oceanic processes affect the intensity and distribution of toxin-producing HABs and to understand the potential health risks from exposure even to low levels of their potent neurotoxins, especially during susceptible stages of life. Three distinct research projects will explore environmental controls of bloom occurrence, create numerical models to predict the exposure of human population to toxins under changing climate conditions, and study the effects of HAB toxins on the brain. The administrative core of the Center will connect these projects, encouraging open discussion of planning, integration, communication and enhancing diverse perspectives, and providing rigorous evaluation of progress in all aspects of the program. The Center’s Community Engagement Core will facilitate integration of the research with education and engagement of resource managers and other stakeholders. The Center will improve awareness of emerging HAB issues for the public health community and develop new educational materials and interactive activities for K-12 classrooms, and for health care providers. The Center is jointly supported by NSF’s Division of Ocean Sciences and by the National Institute for Environmental Health Sciences (NIEHS).The Center will focus on two key HAB taxa: Alexandrium catenella, which produces the saxitoxins responsible for paralytic shellfish poisoning (PSP), and Pseudo-nitzschia spp., which produce domoic acid responsible for amnesic shellfish poisoning (ASP) syndrome; both are expanding geographically. Novel, targeted, efficient, and data-rich sampling approaches developed by the applicants and applied in situ in natural settings have revealed new controls of A. catenella population dynamics, and have identified possible new climate links regarding toxic Pseudo-nitzschia species. Project 1 will examine further the physiological and climatic variables affecting these HABs, which may underlie population adaptation in different habitats and different environmental regimes. Project 2 will incorporate these new and fundamental insights on bloom regulation into coupled climate-population models to predict HAB threats under future climate scenarios, a key step toward being able to quantify future risks from this recurrent public health threat. In biomedical studies with the zebrafish model, Project 3 has identified myelination in the developing brain as a target of domoic acid. This project will use transgenic zebrafish and single-cell RNA-sequencing to identify the cell-specific mechanisms underlying effects of domoic acid, saxitoxin, and the cyanotoxin anatoxin-a in zebrafish embryos in vivo and will use human iPSC-derived 3D brain systems in vitro to elucidate toxin effects on neural and glial cell differentiation in human cells. Effects of different HAB toxin co-exposures will be examined in early life stages and adults. Through this multidisciplinary collaborative and integrated approach, all three projects will link oceanic processes to human exposure, helping to define the exposure of susceptible human subpopulations and predict the effects of a changing climate.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

伍兹孔海洋和人类健康中心是为期五年的努力，旨在解决气候变化如何影响有害的藻华（HAB）动态和人类对HAB毒素的暴露，这是一种严重而全球的人类健康威胁。总体目的是通过加强对气候和海洋过程如何影响产生毒素HAB的强度和分布的理解，并了解潜在的健康风险，甚至在其潜在的神经毒素水平较低的水平，尤其是在易感生命的阶段，从而了解潜在的健康风险，从而保护公共卫生。三个不同的研究项目将探索盛开的环境控制，创建数值模型，以预测人口在变化的气候条件下对毒素的暴露，并研究HAB毒素对大脑的影响。该中心的行政核心将连接这些项目，鼓励对计划，整合，沟通和增强不同观点的公开讨论，并在计划的各个方面对进度进行严格的评估。该中心的社区参与核心将有助于将研究与资源经理和其他利益相关者的教育和参与。该中心将提高人们对公共卫生社区新兴HAB问题的认识，并为K-12教室和医疗保健提供者开发新的教育材料和互动活动。 The Center is jointly supported by NSF’s Division of Ocean Sciences and by the National Institute for Environmental Health Sciences (NIEHS).The Center will focus on two key HAB taxa: Alexandrium catenella, which produces the saxitoxins responsible for paralytic shellfish poisoning (PSP), and Pseudo-nitzschia spp., which produce domoic acid responsible for amnesic shellfish poisoning (ASP)综合征；两者在地理上都在扩展。申请人开发的新颖，有针对性，高效和数据丰富的抽样方法并在自然环境中应用原位揭示了对Catenella a链烷烷种群动态的新控制，并已经确定了有关有毒伪nitzschia物种的可能的新气候联系。项目1将进一步研究影响这些HAB的物理和杂交变量，这可能是不同栖息地和不同环境制度的人口适应的基础。项目2将将这些关于布鲁姆法规的新的和基本的见解纳入耦合的气候人群模型中，以预测未来气候场景下的HAB威胁，这是能够从这种反复出现的公共卫生威胁中量化未来风险的关键一步。在使用斑马鱼模型的生物医学研究中，项目3已将发育中的大脑中的髓鞘形成为多糖酸的靶标。该项目将使用转基因斑马鱼和单细胞RNA测序来识别二氧酸，saxitoxin和cyanotoxin Anatoxin-a在体内胚胎胚胎中的细胞特异性机制，并将使用人类IPSC衍生的3D脑系统在体内使用人物差异效应，并将其用于Neurucation and neurucation and Neurony and Neurony and Neurony and Neurony and Neurony and Neurony and and and and neurony。不同的HAB毒素共曝光的影响将在早期和成年人的早期阶段进行检查。通过这种多学科的合作和综合方法，这三个项目都将海洋过程与人类接触联系起来，有助于定义易感人类亚群体的暴露并预测气候变化的影响。这项奖项反映了NSF的法定任务，并通过使用该基金会的知识分子的智力和广泛的影响来评估NSF的法定任务，并被认为是珍贵的支持。