Understanding the complex cellular dynamics of Multiple Sclerosis pathophysiology: In vivo imaging of immune cells, CNS endogenous cells and the demyelinating axon in Multiple Sclerosis and its animal model

了解多发性硬化症病理生理学的复杂细胞动力学：多发性硬化症及其动物模型中免疫细胞、中枢神经系统内源性细胞和脱髓鞘轴突的体内成像

• 批准号: 263020259
• 负责人: Privatdozent Dr. Volker Siffrin
• 金额: --
• 依托单位: Experimental and Clinical Research Center (ECRC)
• 依托单位国家: 德国
• 项目类别: Heisenberg Fellowships
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/263020259?language=en
• 关键词: Understanding; complex; cellular; dynamics; Multiple

The precondition for a Heisenberg Programme funding is high scientific quality and originality of the research project at international level and suitability for further qualification as a university teacher. Applicants need to meet all the requirements for appointment to a permanent professorship.The aim of this programme is to enable outstanding scientists to prepare for a scientific leadership function, and simultaneously work on further research topics. This research does not necessarily need to be planned and carried out in the form of a project.For this reason, and unlike the procedure in other funding programmes, both the abstracts of applications and final reports are not required and will therefore not be published in GEPRIS.

海森堡计划资助的先决条件是高科学质量和国际水平的研究项目的原创性，并适合作为大学教师的进一步资格。申请人需要满足任命为永久教授的所有要求。该计划的目的是使杰出的科学家为科学领导职能做好准备，同时从事进一步的研究课题。这项研究并不一定需要以项目形式规划和进行，因此，与其他资助计划的程序不同，申请摘要和最后报告都不需要，因此不会在GEPRIS上发表。

项目成果

HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation

• DOI: 10.1002/glia.24380
• 发表时间: 2023-05
• 期刊: Glia
• 影响因子: 6.2
• 作者: K. Rosiewicz;B. Muinjonov;Séverine Kunz;H. Radbruch;Jessy Chen;R. Jüttner;Janis Kerkering;Julia Ucar;Tadhg Crowley;B. Wielockx;Friedemann Paul;Marlen Alisch;Volker Siffrin

Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation

• DOI: 10.1016/j.jneumeth.2021.109284
• 发表时间: 2021-07-21
• 期刊: JOURNAL OF NEUROSCIENCE METHODS
• 影响因子: 3
• 作者: Alisch, Marlen;Kerkering, Janis;Siffrin, Volker
• 通讯作者: Siffrin, Volker

CCR7 on CD4+ T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis

• DOI: 10.4049/jimmunol.1701419
• 发表时间: 2018-04-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Belikan, Patrick;Buelller, Ulrike;Siffrin, Volker
• 通讯作者: Siffrin, Volker

Comparison of RNA isolation procedures for analysis of adult murine brain and spinal cord astrocytes

用于分析成年小鼠大脑和脊髓星形胶质细胞的 RNA 分离程序的比较

• DOI: 10.1016/j.jneumeth.2019.108545
• 发表时间: 2020
• 期刊: Journal of Neuroscience Methods
• 影响因子: 3
• 作者: Rosiewicz;Crowley;Kerkering;Alisch;Siffrin
• 通讯作者: Siffrin

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression

对临床孤立综合征中 T 细胞/单核细胞比率的流式细胞术分析可识别处于疾病快速进展风险的患者

• DOI: 10.1177/1352458515593821
• 发表时间: 2016
• 期刊: Multiple Sclerosis Journal
• 影响因子: 5.8
• 作者: Nemecek;Zimmermann;Rübenthaler;Fleischer;Paterka;Luessi;Müller-Forell;Siffrin
• 通讯作者: Siffrin