Influence of the EphrinB2-EphB4 system on spinal metastasis formation

EphrinB2-EphB4系统对脊柱转移瘤形成的影响

• 批准号: 267716524
• 负责人: Professor Dr. Marcus Czabanka
• 金额: --
• 依托单位: Klinik und Poliklinik für Neurochirurgie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/267716524?language=en
• 关键词: Influence; EphrinB2; EphB4; system; spinal

The herein presented project analyses organspecific tumor cell dissemination with a special focus on the generation of manifest spinal metastasis. For this purpose an established experimental animal model (intraarteriel tumor cell injection) is used in combination with bioluminescence imaging and smal animal MR imaging. Using a transgenic animal model (endothelial EphrinB2 KO) and EphB4 manipulated tumor cells, the role of the EphrinB2-EphB4 pathway for the generation of spinal metastasis is investigated. Translational therapy experiments with EphrinB2-EphB4 altering substances will highlight the importance of this signalling pathway as a suitable target to treat spinal metastasis. The focus of cellular analysis will analyse tumor cell-endothelia cell interactions in relation to EphrinB2-EphB4 alterations. The overall aim of this research project is to identify the EphrinB2-EphB4 system as a key regulator of spinal metastasis and a clinically promising therapy strategy.

本文介绍的项目分析了器官特异性肿瘤细胞的传播，特别关注明显的脊柱转移的产生。为此目的，将建立的实验动物模型（动脉内肿瘤细胞注射）与生物发光成像和小动物MR成像结合使用。使用转基因动物模型（内皮EphrinB 2 KO）和EphB 4操纵的肿瘤细胞，研究EphrinB 2-EphB 4途径对于产生脊柱转移的作用。用EphrinB 2-EphB 4改变物质的转化治疗实验将突出这种信号传导途径作为治疗脊柱转移的合适靶点的重要性。 细胞分析的重点将分析与EphrinB 2-EphB 4改变相关的肿瘤细胞-内皮细胞相互作用。本研究项目的总体目标是确定EphrinB 2-EphB 4系统作为脊柱转移的关键调节因子和临床上有前途的治疗策略。

项目成果

ICAM1 depletion reduces spinal metastasis formation in vivo and improves neurological outcome

• DOI: 10.1007/s00586-015-3811-7
• 发表时间: 2015-10-01
• 期刊: EUROPEAN SPINE JOURNAL
• 影响因子: 2.8
• 作者: Broggini, Thomas;Czabanka, Marcus;Vajkoczy, Peter
• 通讯作者: Vajkoczy, Peter

Role of mTOR and VEGFR Inhibition in Prevention of Metastatic Tumor Growth in the Spine

• DOI: 10.3389/fonc.2020.00174
• 发表时间: 2020-02-19
• 期刊: FRONTIERS IN ONCOLOGY
• 影响因子: 4.7
• 作者: Kratzsch, Tobias;Piffko, Andras;Vajkoczy, Peter
• 通讯作者: Vajkoczy, Peter