Regulation of bone formation and resorption by osteoblastic EphrinB2/EphB4 signalling

成骨细胞 EphrinB2/EphB4 信号传导对骨形成和骨吸收的调节

• 批准号: nhmrc : 1042129
• 负责人: A/Pr Natalie Sims
• 金额: $ 43.24万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-bone-formation-ephrinb2ephb4-signalling/111440
• 关键词: Regulation; bone; formation; resorption; osteoblastic

Skeletal strength is maintained by balanced cycles of bone resorption and bone formation. Cells that live inside the bone matrix, osteocytes, are thought to co-ordinate this. We have found that two proteins, EphrinB2 and EphB4, exist on the surface of osteocytes and regulate bone formation and resorption. This project investigates how they do this, and whether interfering with or enhancing their signals could be used to increase bone strength in osteoporosis.

骨骼强度通过骨吸收和骨形成的平衡循环来维持。生活在骨基质内的细胞，骨细胞，被认为是协调这一点的。我们已经发现两种蛋白质EphrinB2和EphB4存在于骨细胞表面并调节骨形成和吸收。该项目研究了它们是如何做到这一点的，以及干扰或增强它们的信号是否可以用来增加骨质疏松症的骨强度。