The Tumor Microenvironment: Cross-talk between cancer cells and non-cancer cells

肿瘤微环境：癌细胞和非癌细胞之间的串扰

• 批准号: 268358822
• 负责人: Professorin Dr. Elke Pogge von Strandmann
• 金额: --
• 依托单位: Zentrum für Tumor- und Immunbiologie (ZTI)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/268358822?language=en
• 关键词: Tumor; Microenvironment; Cross; talk; between

Aim of this project is to contribute to a better understanding of the cross-talk between cancer cells and non-cancer cells within the tumor tissue. We hypothesize that these interactions are required to accomplish tumor hallmarks including immune evasion, growth factor independence/apoptosis resistance, angiogenesis and motility. The dialogue between the genetically altered malignant cells and the supporting cells of the microenvironment are critical to understanding cancer pathogenesis and - on the long run - to the development of novel, effective therapies.Specifically, the impact of the interaction of cancer cells with non-malignant cells on the phenotype and the functions of the interacting cells will be addressed. The role of cell-cell communication for the differentiation of the tumor towards activation of programs that allow the achievements of classical and emerging cancer cell hallmarks (such as the induction of immune evasion or even tumor-supportive functions of immune cells) will be investigated. To tackle these questions including the composition, structure and function of the tumor microenvironment several in vitro approaches and animal models are used, which requires an highly interdisciplinary approach covering the medical and natural sciences. Within this proposal we plan to support a close collaboration for basic and translational orientated researchers within this research area especially through the allocation of a structured educational program. The measurements include technical trainings and soft skill workshops, and provide a platform to facilitate the exchange of material and techniques between the projects to improve research projects directly. Selected projects and their students may be supported with travel grants to national/international meetings or conferences. A scholarship opportunity should allow internships abroad e.g. to learn novel techniques that foster the progress of a doctoral thesis. We expect synergisms not only supporting competitive high quality PhD and MD dissertations but also facilitating the interactions between basic scientists and clinicians, resulting in an improved biological understanding of the tumor microenvironment.

这个项目的目的是为了更好地了解肿瘤组织中癌细胞和非癌细胞之间的相互作用。我们假设，这些相互作用是实现肿瘤特征所必需的，包括免疫逃避、生长因子独立/凋亡抵抗、血管生成和运动性。基因改变的恶性细胞和微环境的支持细胞之间的对话对于理解癌症的发病机制以及从长远来看对于开发新的有效治疗方法至关重要。具体地说，将讨论癌细胞与非恶性细胞相互作用对相互作用细胞的表型和功能的影响。我们将研究细胞-细胞通讯在肿瘤分化过程中所起的作用，以激活能够实现经典和新兴癌细胞特征的程序(如诱导免疫逃避，甚至免疫细胞的肿瘤支持功能)。为了解决这些问题，包括肿瘤微环境的组成、结构和功能，人们使用了几种体外方法和动物模型，这需要涵盖医学和自然科学的高度跨学科的方法。在这项提议中，我们计划支持基础研究和面向翻译的研究人员在这一研究领域内的密切合作，特别是通过分配一个结构化的教育计划。这些措施包括技术培训和软技能讲习班，并提供了一个平台，促进项目之间的材料和技术交流，以直接改进研究项目。选定的项目及其学生可获得参加国家/国际会议或大会的旅费补助金。奖学金机会应该允许在国外实习，例如学习有助于博士论文进步的新技术。我们期望协同效应不仅支持竞争激烈的高质量博士和医学博士论文，而且还促进基础科学家和临床医生之间的互动，从而改善对肿瘤微环境的生物学理解。