The Reelin-GPVI axis in acute myocardial infarction beyond thrombosis (A05)

Reelin-GPVI 轴在血栓以外的急性心肌梗死中的应用 (A05)

• 批准号: 269662993
• 金额: --
• 依托单位: Klinik für Gefäß- und Endovaskularchirurgie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269662993?language=en
• 关键词: Reelin; GPVI; axis; acute; myocardial

TP A05 aims to understand the impact of platelets in inflammation, cell survival and scar formation and the role of the glycoprotein VI (GPVI)-Reelin axis in these processes post AMI. We will investigate non hemostatic/thrombotic functions of platelets with respect to platelet-mediated inflammation and platelet-induced cardiomyocyte survival and fibroblast activation post AMI. The role of Reelin in GPVI mediated platelet activation and the impact of Reelin post AMI will be determined using an antibody that blocks Reelin oligomerisation and Reelin mutant mice.

TP A05旨在了解血小板在炎症、细胞存活和瘢痕形成中的影响，以及糖蛋白VI（GPVI）-Reelin轴在AMI后这些过程中的作用。我们将研究血小板的非止血/血栓形成功能与血小板介导的炎症和血小板诱导的心肌细胞存活和AMI后成纤维细胞活化的关系。将使用阻断Reelin寡聚化的抗体和Reelin突变小鼠来确定Reelin在GPVI介导的血小板活化中的作用和Reelin在AMI后的影响。