The Reelin-GPVI axis in acute myocardial infarction beyond thrombosis (A05)

TP A05旨在了解血小板在AMI后炎症、细胞存活和疤痕形成中的影响，以及糖蛋白VI (GPVI)-Reelin轴在这些过程中的作用。我们将研究AMI后血小板介导的炎症和血小板诱导的心肌细胞存活和成纤维细胞活化方面血小板的非止血/血栓功能。Reelin在GPVI介导的血小板活化中的作用以及AMI后Reelin的影响将通过阻断Reelin寡聚化和Reelin突变小鼠的抗体来确定。

TP A05 aims to understand the impact of platelets in inflammation, cell survival and scar formation and the role of the glycoprotein VI (GPVI)-Reelin axis in these processes post AMI. We will investigate non hemostatic/thrombotic functions of platelets with respect to platelet-mediated inflammation and platelet-induced cardiomyocyte survival and fibroblast activation post AMI. The role of Reelin in GPVI mediated platelet activation and the impact of Reelin post AMI will be determined using an antibody that blocks Reelin oligomerisation and Reelin mutant mice.