Investigation of the role for GPVI in platelet function and thrombosis

GPVI 在血小板功能和血栓形成中的作用研究

• 批准号: nhmrc : 491166
• 负责人: Prof Shaun Jackson
• 金额: $ 36.19万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-role-gpvi-function-thrombosis/96593
• 关键词: Investigation; role; GPVI; platelet; function

Blood cells play an important role in maintaining healthy blood vessels. We are studying the role of platelets in blood clots following vessel injury. However, while critical for normal blood vessel maintenance, these cells also contribute to diseases including thrombosis. We will examine how an important platelet receptor called GPVI promotes blood clot formation, and examine whether combining anticoagulant drugs with GPVI deficient platelets leads to a more effective anticlotting approach.

血细胞在维持血管健康方面发挥着重要作用。我们正在研究血小板在血管损伤后的血凝块中的作用。然而，虽然这些细胞对正常血管的维持至关重要，但它们也会导致包括血栓形成在内的疾病。我们将研究一种重要的血小板受体GPVI是如何促进血凝块形成的，并研究抗凝药物与GPVI缺陷的血小板结合是否会导致更有效的抗凝方法。