Combined genetic and cellular analysis of melanisation to study variation in human pigmentation

结合黑化的遗传和细胞分析来研究人类色素沉着的变化

• 批准号: DP0771169
• 负责人: A/Prof Richard Sturm
• 金额: $ 34.34万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0771169
• 关键词: Combined; genetic; cellular; analysis; melanisation

This investigation examines variations in the genes that are important determinants of human skin pigmentation and are likely to be associated with skin cancer risk. Our research program will form the basis of future diagnostics based on major genes that determine a persons skin type. Current skin cancer prevention strategies rely predominantly on broad spectrum campaigns that are aimed at increasing the general community awareness of the damaging effects of UV radiation. A better understanding of the genetic basis of UV-sensitive skin types will greatly enhance the targeting of such skin cancer-prevention campaigns, provide an understanding of changes that occur in skin pathology, and the mechanisms of sun induced tanning.

这项研究考察了人类皮肤色素沉着的重要决定因素基因的变异，这些基因可能与皮肤癌风险有关。我们的研究计划将形成基于主要基因的未来诊断的基础，这些基因决定了一个人的皮肤类型。目前的皮肤癌预防战略主要依赖于广泛的宣传活动，旨在提高公众对紫外线辐射破坏性影响的认识。更好地了解对紫外线敏感的皮肤类型的遗传基础将极大地提高皮肤癌预防运动的目标，提供对皮肤病理发生的变化的理解，以及太阳诱导晒黑的机制。