Molecular, genetic and cellular analysis of melanisation in human pigmentation

人类色素沉着黑色化的分子、遗传和细胞分析

• 批准号: DP1094964
• 负责人: A/Prof Richard Sturm
• 金额: $ 29.89万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094964
• 关键词: Molecular; genetic; cellular; analysis; melanisation

This investigation examines variations in the genes that determine human skin pigmentation and are likely to be associated with skin cancer risk. Our research program will form the basis of future diagnostics based on major genes that determine a persons skin type. Current skin cancer prevention strategies rely predominantly on broad spectrum campaigns that are aimed at increasing the general community awareness of the damaging effects of ultraviolet (UV) radiation. A better understanding of the genetic basis of UV-sensitive skin types will greatly enhance the targeting of such skin cancer-prevention campaigns, provide an understanding of changes that occur in skin pathology, and the mechanisms of sun induced tanning.

这项研究检查了决定人类皮肤色素沉着的基因变异，并可能与皮肤癌风险有关。 我们的研究计划将成为未来基于决定一个人皮肤类型的主要基因的诊断的基础。 目前的皮肤癌预防策略主要依赖于广谱运动，旨在提高公众对紫外线（UV）辐射的破坏性影响的认识。 更好地了解紫外线敏感皮肤类型的遗传基础将大大提高这种皮肤癌预防活动的针对性，提供对皮肤病理学变化的理解，以及太阳诱导晒黑的机制。