Pathways of the cholinergic anti-inflammatory reflex in arthritis
Pathways of the cholinergic anti-inflammatory reflex in arthritis
批准号:
278103889
负责人:
Professor Dr. Rainer H. Straub
金额:
$0.0万
依托单位国家:
德国
项目类别:
Research Grants
财政年份:
2015
资助国家:
德国
项目状态:
已结题
起止时间:
2014-12-31 至 2018-12-31
中文摘要
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英文摘要
Since the discovery of the cholinergic anti-inflammatory pathway there was much debate whether it can be valuable in chronic arthritis. It is accepted that the alpha7 subunit nicotinergic acetylcholine receptor (alpha7nAChR) is instrumental in anti-inflammatory effects because alpha7nAChR agonists are beneficial in arthritis. In this project, three major aspects of the cholinergic pathway will be investigated. 1) Chronic electrical vagus nerve stimulation (VNS) will be applied over 40d in arthritic rats in order to characterize the involved efferent axis (alpha7nAChR antagonist [testing the cholinergic pathway], or with blockade of the hypothalamic-pituitary-adrenal axis, or with inhibition of the sympathetic nervous system). 2) Recent studies of our group demonstrated that catecholaminergic sympathetic nerve fibers can be converted to a cholinergic phenotype by leukemia inhibitory factor and progesterone. In this project, this concept will be used in rats to partly change the phenotype of sympathetic nerve fibers, thereby, inducing a cholinergic milieu before and after immunization with collagen type II. We expect that either goal 1) or goal 2) or both show beneficial, anti-arthritic effects in rats but the responsible cell type is not clear from these in vivo studies. However, we expect that regulatory T cells play a major role. 3) Thus, the most beneficial, anti-arthritic strategy of part 1 or part 2 will be used to test whether regulatory T cells separated from lymphoid organs - transfer these favorable effects. Hence, donors with arthritis will be treated with the most beneficial strategy, regulatory T cells will be removed from donor spleen, and these cells will be transferred to arthritic recipients. This will show us the cellular route of influence. We expect major new findings in relation to the cholinergic anti-inflammatory pathway that might be suitable as a future therapeutic strategy.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
DOI:
10.14814/phy2.13953
发表时间:
2018-12-01
期刊:
PHYSIOLOGICAL REPORTS
影响因子:
2.5
作者:
[Stauss, Harald M., Stangl, Hubert, Lira, Vitor A.]
通讯作者:
Lira, Vitor A.
DOI:
10.1016/j.bbi.2016.02.006
发表时间:
2016-05-01
期刊:
BRAIN BEHAVIOR AND IMMUNITY
影响因子:
15.1
作者:
[Klatt, Susanne, Stangl, Hubert, Straub, Rainer H.]
通讯作者:
Straub, Rainer H.
G(alpha)S-to-G(alpha)i switch of G protein-coupled receptor signalling in arthritis
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批准号:355701977
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项目类别:Research Grants
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资助金额:$0.0万
-
财政年份:2017
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Role of dendritic cells in adrenal glands of healthy and arthritic rats
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批准号:235438724
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2013
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Anti-inflammatory pathways of catecholaminergic, tyrosine hydroxylase (TH) - positive cells in human and experimental arthritis
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批准号:243785207
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2013
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
The blockade of neuropilin-2 / plexin A2 as therapeutic principle in arthritis
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批准号:163601529
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项目类别:Research Units
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资助金额:$0.0万
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财政年份:2010
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Verwaltungsprojekt
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批准号:163664595
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项目类别:Research Units
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资助金额:$0.0万
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财政年份:2010
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Zentralprojekt
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批准号:27911654
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项目类别:Research Units
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资助金额:$0.0万
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财政年份:2006
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Role of tyrosine-hydroxylase (TH) - positive cells during inflammatory processes in arthritis
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批准号:27910539
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项目类别:Research Units
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资助金额:$0.0万
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财政年份:2006
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
The blockade of neuropilin-2 as a new therapeutic principle in arthritis
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批准号:27828897
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项目类别:Research Units
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资助金额:$0.0万
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财政年份:2006
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Rolle von Tyrosin-Hydroxylase (TH) - positiven Zellen im Rahmen des Entzündungsgeschehens bei Arthritis
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批准号:5441750
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2005
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Die Blockade des Neuropilin-2 als neues therapeutisches Prinzip bei Arthritis
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批准号:5450563
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2005
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Produktionsstätte von Nerve Repellent Factors und Bedeutung derselben für den Rückzug sympathischer Nervenfasern im Synovialgewebe bei Arthritis
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批准号:5343298
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:2001
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Der superfundierte Gewebeschnitt als Modell für eine lokale Bakterienbesiedlung zur Untersuchung der Interaktion von Bakterien, Makrophagen, Neurotransmittern und Glukokortikoiden
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批准号:5210118
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:1999
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
Einfluß endogener Neurotransmitter auf die IL-6-, IL-8- und Matrixmetalloproteinase 3-Sekretion des arthritischen und osteoarthrotischen Synovialgewebes des Menschen
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批准号:5096944
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项目类别:Research Grants
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资助金额:$0.0万
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财政年份:1997
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负责人:Professor Dr. Rainer H. Straub
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依托单位:
海外基金