Role of tyrosine-hydroxylase (TH) - positive cells during inflammatory processes in arthritis

酪氨酸羟化酶（TH）阳性细胞在关节炎炎症过程中的作用

• 批准号: 27910539
• 负责人: Professor Dr. Rainer H. Straub
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin I
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2011-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/27910539?language=en
• 关键词: Role; tyrosine; hydroxylase; TH; positive

In rheumatoid arthritis a massive loss of tyrosine hydroxylase (TH)-positive (sympathetic) nerve fibres and a clear increase of TH-positive cells in inflamed synovial tissue of humans was found during inflammation (own previous work). Most probably these cells are sympatho-adrenergic cells (own previous work). The role these cells play in inflammation is totally unclear. Therefore, in this application, we want to scrutinise the following points: 1. Under which conditions do these cells produce catecholamines?2. How do these cells modulate the function of synovial macrophages and fibroblasts and how dothe macrophages and fibroblasts modulate the secretion of catecholamines?3. Are these cells proinflammatory and how would the their removal influence the course of experimental arthritis?4. How is TH regulated in TH-positive cells from human synovia (alternative splicing?)5. Does norepinephrine produced by these cells interfere with conversion of 17ß-estradiol to2-methoxyestradiol?These experiments will shed light on the importance of TH-positive cells in arthritis and might lead to new therapeutic principles for arthritis.

在类风湿性关节炎中，在炎症过程中发现人类炎症滑膜组织中酪氨酸羟化酶（TH）阳性（交感神经）神经纤维大量丢失，TH阳性细胞明显增加（自己以前的工作）。这些细胞很可能是交感肾上腺素能细胞（自己以前的工作）。这些细胞在炎症中的作用还完全不清楚。因此，在本申请中，我们要仔细研究以下几点：1。在什么条件下这些细胞产生儿茶酚胺？2.这些细胞如何调节滑膜巨噬细胞和成纤维细胞的功能，巨噬细胞和成纤维细胞如何调节儿茶酚胺的分泌？3.这些细胞是促炎细胞吗？它们的去除会如何影响实验性关节炎的进程？4.人滑膜TH阳性细胞中TH是如何调节的（选择性剪接？）5.这些细胞产生的去甲肾上腺素是否会干扰17 β-雌二醇向2-甲氧基雌二醇的转化？这些实验将揭示TH阳性细胞在关节炎中的重要性，并可能导致关节炎的新治疗原则。