Zentralprojekt

中央项目

• 批准号: 27911654
• 负责人: Professor Dr. Rainer H. Straub
• 金额: --
• 依托单位: Klinik und Poliklinik für Innere Medizin I
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/27911654?language=en
• 关键词: Zentralprojekt

Damage and regeneration are central mechanisms of bone and connective tissue homeostasis. Effectors of these mechanisms are cells of mesenchymal origin (mesenchymal stem cells, fibroblasts, chondrocytes, osteoblasts, osteoclasts, immune cells, etc.). Activation of inherited programs by endogenous or exogenous stimuli via cellular or humoral factors might support protective or destructive processes. Involved compartments of the joint are the more static structures such as cartilage and bone and the more dynamic structures such as synovium and periost. During the last 2½ years, the contents of a promising research program evolved and interactive fruitful cooperations between different groups of the University were established. An intramural program successfully linked departments of surgery (orthopaedic surgery, trauma surgery), internal medicine (rheumatology / clinical immunology), pathology, pharmaceutical technology, and mechanical engineering. In the present proposal, we will investigate neuroendocrine immune mechanisms for repair of cartilage and bone, for differentiation of mesenchymal stem cells, and for inflammatory processes in rheumatoid arthritis and experimental arthritis. This research program might enable us to define new therapeutic targets for joint and bone diseases.

损伤和再生是骨和结缔组织稳态的中心机制。这些机制的效应子是间充质来源的细胞（间充质干细胞、成纤维细胞、软骨细胞、成骨细胞、破骨细胞、免疫细胞等）。通过细胞或体液因素的内源性或外源性刺激激活遗传程序可能支持保护或破坏过程。关节的受累隔室是更静态的结构，如软骨和骨，以及更动态的结构，如滑膜和骨膜。在过去的2年半里，一个有前途的研究计划的内容演变和大学的不同群体之间建立了互动富有成效的合作。一个校内项目成功地将外科（矫形外科、创伤外科）、内科（风湿病学/临床免疫学）、病理学、制药技术和机械工程等部门联系起来。在本提案中，我们将调查神经内分泌免疫机制修复软骨和骨，间充质干细胞的分化，并在类风湿性关节炎和实验性关节炎的炎症过程。这项研究计划可能使我们能够为关节和骨骼疾病确定新的治疗靶点。