Role of the PU.1 transcription factor in regulating lymphoid development

PU.1转录因子在调节淋巴发育中的作用

• 批准号: DP0774639
• 负责人: Dr Sebastian Carotta
• 金额: $ 15.72万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0774639
• 关键词: Role; PU.1; transcription; factor; regulating

Haemopoiesis is a tightly regulated process and provides an important model for our understanding and application of stem cell biology. Perturbation of early haemopoiesis results in a number of important disorders including leukaemia, anaemia and immunodeficiency. The application of stem cells to many disease conditions is currently being pursued, however, in order to develop therapeutic interventions knowledge of normal cellular differentiation is crucial. The studies outlined here aim to contribute to the understanding of the these processes and hence help to provide the framework for future studies aimed at more directly altering cell fate decision for clinical applications.

造血是一个严格调控的过程，为我们理解和应用干细胞生物学提供了一个重要的模型。早期造血功能的紊乱会导致许多重要的疾病，包括白血病、贫血和免疫缺陷。目前正在寻求将干细胞应用于许多疾病状况，然而，为了开发治疗干预措施，正常细胞分化的知识是至关重要的。本文概述的研究旨在促进对这些过程的理解，从而有助于为未来的研究提供框架，旨在更直接地改变临床应用的细胞命运决定。