Production of large scale erythroid progenitor cultures from human embryonic stem cells

将正确血型的新鲜红细胞单位输入患者体内可以挽救生命。然而，由于捐献者的血液供应有限，而且其保质期很短，因此需要持续的献血者血液供应，因此获得正确血型的单位往往受到限制。我们建议开发一种系统，允许我们在培养皿中产生无限数量的人类红细胞，我们将通过分化人类胚胎干细胞系来获得这种培养皿。

Transfusion of fresh red blood cell units of the correct blood type into patients can be life saving. However, access to units of the correct blood type is often limited due to limited supply of donor blood and its short shelf life creating the need for a constant donor blood supply. We propose to develop a system that allows us to generate unlimited numbers of human red blood cells in a culture dish which we will derive from differentiating human embryonic stem cell lines.