Production of large scale erythroid progenitor cultures from human embryonic stem cells

利用人类胚胎干细胞大规模生产红系祖细胞培养物

• 批准号: nhmrc : 1017180
• 负责人: Dr Sebastian Carotta
• 金额: $ 26.45万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Development Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/production-large-scale-stem-cells/109835
• 关键词: Production; large; scale; erythroid; progenitor

Transfusion of fresh red blood cell units of the correct blood type into patients can be life saving. However, access to units of the correct blood type is often limited due to limited supply of donor blood and its short shelf life creating the need for a constant donor blood supply. We propose to develop a system that allows us to generate unlimited numbers of human red blood cells in a culture dish which we will derive from differentiating human embryonic stem cell lines.

将正确血型的新鲜红细胞单位输注到患者体内可以挽救生命。然而，由于供体血液的供应有限及其短的保质期，获得正确血型的单位往往是有限的，需要不断的供体血液供应。我们建议开发一种系统，使我们能够在培养皿中产生无限数量的人类红细胞，我们将从分化的人类胚胎干细胞系中获得。