A transcription factor network constraining the development of B cell leukaemia

B细胞白血病是相对常见的，通常是侵袭性的造血恶性肿瘤，其病因在许多情况下是未知的。我们发现，通常控制B细胞分化的几个转录因子的缺陷导致B细胞白血病的频率很高。我们希望确定由这些因子调控的关键途径，并在正常细胞中阻止白血病转化。这将有助于确定治疗干预的潜在目标。

B cell leukemias are relatively common, often aggressive hematopoietic malignancies and their cause is unknown in many cases. We have found that deficiencies in several transcription factors that normally control B cell differentiation cause B cell leukemias at a high frequency. We wish to identify the key pathways that are regulated by these factors and, in normal cells, prevent leukemic transformation. This will help to identify potential targets for therapeutic intervention.