Transcriptional regulation of hematopoietic commitment

造血承诺的转录调控

• 批准号: nhmrc : 1011808
• 负责人: Dr Sebastian Carotta
• 金额: $ 19.34万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-regulation-hematopoietic-commitment/109618
• 关键词: Transcriptional; regulation; hematopoietic; commitment

Blood cell formation is a tightly regulated process and provides an important model for our understanding of blood homeostasis. Perturbations result in a number of disorders such as leukaemia. The application of stem cells to many diseases is being pursued; yet, to be successful knowledge of normal cellular behavior is crucial. I aim to improve our understanding of these processes and help to provide the framework for future studies aimed at more directly manipulating blood cell functions.

血细胞的形成是一个严格调控的过程，为我们理解血液稳态提供了一个重要的模型。扰动导致许多疾病，如白血病。干细胞在许多疾病中的应用正在被追求;然而，要成功地了解正常细胞行为是至关重要的。我的目标是提高我们对这些过程的理解，并帮助为未来旨在更直接地操纵血细胞功能的研究提供框架。