Transcriptional regulation of specialized subsets of dendritic cells in control of infection

树突状细胞特殊亚群的转录调控控制感染

• 批准号: nhmrc : 1023266
• 负责人: Dr Sebastian Carotta
• 金额: $ 41.14万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-regulation-specialized-control-infection/110262
• 关键词: Transcriptional; regulation; specialized; subsets; dendritic

Immune protection against viruses and bacteria depends on specialized cells called dendritic cells that display components of the invading organisms on their surface. There are multiple different types of dendritic cell and each population plays a specialized role in defending the body against infection. Our work will provide the framework for directly targeting these cells for novel vaccines to re-program the immune system for clinical conditions such as cancer, allergy and autoimmunity.

针对病毒和细菌的免疫保护依赖于称为树突细胞的专门细胞，这些细胞在其表面展示入侵生物体的成分。有多种不同类型的树突状细胞，每种细胞群在保护身体免受感染方面都起着特殊的作用。我们的工作将为直接靶向这些细胞的新型疫苗提供框架，以重新编程免疫系统，用于癌症，过敏和自身免疫等临床疾病。