Transcriptional regulation of specialized subsets of dendritic cells in control of infection

对病毒和细菌的免疫保护依赖于称为树突状细胞的特殊细胞，树突状细胞在其表面显示入侵生物体的成分。树突状细胞有多种不同的类型，每种类型的树突状细胞在保护身体免受感染方面都起着特殊的作用。我们的工作将为直接靶向这些细胞的新型疫苗提供框架，以重新编程免疫系统，以治疗癌症、过敏和自身免疫等临床疾病。

Immune protection against viruses and bacteria depends on specialized cells called dendritic cells that display components of the invading organisms on their surface. There are multiple different types of dendritic cell and each population plays a specialized role in defending the body against infection. Our work will provide the framework for directly targeting these cells for novel vaccines to re-program the immune system for clinical conditions such as cancer, allergy and autoimmunity.