Autophagic vacuole formation in mammalian skeletal muscle; role of FOXO proteins.

哺乳动物骨骼肌中自噬液泡的形成；

• 批准号: DP0770546
• 负责人: Prof Mark Febbraio
• 金额: $ 15.72万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0770546
• 关键词: Autophagic; vacuole; formation; mammalian; skeletal

Loss of muscle tissue is a hallmark of many common health problems including cancer, HIV-Aids and renal failure. Recently, we identified that a family of transcription factors termed the forkhead box class-O (FOXO) winged helix transcription factors are key regulators of both anabolic (building) and catabolic (wasting) signalling pathways. This project will investigate the molecular regulation of cell integrity by FOXO proteins. Although very basic in nature, these projects will identify how FOXO proteins regulate muscle cell building and wasting and, therefore, present a potential therapeutic target for muscle wasting diseases, making this project highly significant.

肌肉组织损失是许多常见健康问题的标志，包括癌症、艾滋病毒和肾衰竭。最近，我们发现一个称为叉头盒 O 类 (FOXO) 翼螺旋转录因子的转录因子家族是合成代谢（构建）和分解代谢（消耗）信号通路的关键调节因子。该项目将研究 FOXO 蛋白对细胞完整性的分子调节。尽管本质上非常基础，但这些项目将确定 FOXO 蛋白如何调节肌肉细胞的构建和消耗，因此为肌肉消耗疾病提供潜在的治疗靶点，使该项目非常重要。