An essential role for skeletal muscle FoxO1 in protecting against obesity-induced insulin resistance

骨骼肌 FoxO1 在预防肥胖引起的胰岛素抵抗中发挥重要作用

• 批准号: nhmrc : 1007465
• 负责人: Prof Mark Febbraio
• 金额: $ 39.6万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-essential-role-insulin-resistance/109220
• 关键词: essential; role; skeletal; muscle; FoxO1

Skeletal muscle is the largest organ in the human body and accounts for approximately 80% of glucose disposal after a meal. We have identified a transcription factor, namely FoxO1, that appears protect against obesity-induced insulin resistance by promoting energy consumption. This project will examine whether skeletal muscle specific activation of FoxO1 is a possible therapeutic target for the treatment of obesity-induced insulin resistance.

骨骼肌是人体最大的器官，约占餐后葡萄糖代谢的 80%。我们发现了一种转录因子 FoxO1，它似乎可以通过促进能量消耗来防止肥胖引起的胰岛素抵抗。该项目将研究骨骼肌特异性激活 FoxO1 是否是治疗肥胖引起的胰岛素抵抗的可能治疗靶点。