An essential role for skeletal muscle FoxO1 in protecting against obesity-induced insulin resistance
An essential role for skeletal muscle FoxO1 in protecting against obesity-induced insulin resistance
批准号:
nhmrc : 1007465
负责人:
Prof Mark Febbraio
金额:
$39.6万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
Skeletal muscle is the largest organ in the human body and accounts for approximately 80% of glucose disposal after a meal. We have identified a transcription factor, namely FoxO1, that appears protect against obesity-induced insulin resistance by promoting energy consumption. This project will examine whether skeletal muscle specific activation of FoxO1 is a possible therapeutic target for the treatment of obesity-induced insulin resistance.
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