NAFLD, NASH and Hepatocellular carcinoma: Mechanisms & Potential Treatments

NAFLD、NASH 和肝细胞癌：机制

• 批准号: nhmrc : GNT1122227
• 负责人: Prof Mark Febbraio
• 金额: $ 69.3万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nafld-nash-hepatocellular-potential-treatments/1347259
• 关键词: NAFLD; NASH; Hepatocellular; carcinoma; Mechanisms

Liver cancer is one of the most common and fatal cancers world-wide. In developed countries, the past three decades has seen its incidence treble becoming the fastest rising cause of cancer deaths. In some patients liver cancer seems to be caused by obesity. The reason why some obese patients get liver cancer and others do not is unknown. In addition, there are few treatment options. In these studies we will research what causes liver cancer in obesity and test two new potential therapies.

肝癌是世界上最常见和最致命的癌症之一。在发达国家，过去三十年，其发病率增加了三倍，成为癌症死亡人数上升最快的原因。有些病人的肝癌似乎是由肥胖引起的。有些肥胖患者会得肝癌，而有些则不会，其原因尚不清楚。此外，治疗选择也很少。在这些研究中，我们将研究肥胖导致肝癌的原因，并测试两种新的潜在疗法。