课题基金 / 基金详情

Blocking IL-6 trans-signaling: a therapeutic strategy to prevent metabolic disease

Blocking IL-6 trans-signaling: a therapeutic strategy to prevent metabolic disease
阻断 IL-6 反式信号传导:预防代谢疾病的治疗策略
批准号:
nhmrc : 1041760
负责人:
Prof Mark Febbraio
金额:
$36.05万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31

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中文摘要
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英文摘要
It is well known that blocking the recruitment of specific immune cells namely macrophages to adipose tissue of obese patients will improve their metabolic health. However, to date, a viable drug to do this has remained elusive. We have developed such a drug called sgp130Fc. This project will test the effectiveness of this drug in a pre-clinical setting.
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Mapping and defining inter-organ cross talk during exercise
  • 批准号:
    DP220102500
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $42.51万
  • 财政年份:
    2022
  • 负责人:
    Prof Mark Febbraio
  • 依托单位:
Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease
  • 批准号:
    nhmrc : GNT1116936
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $93.89万
  • 财政年份:
    2017
  • 负责人:
    Prof Mark Febbraio
  • 依托单位:
NAFLD, NASH and Hepatocellular carcinoma: Mechanisms & Potential Treatments
  • 批准号:
    nhmrc : GNT1122227
  • 项目类别:
    Project Grants
  • 资助金额:
    $69.3万
  • 财政年份:
    2017
  • 负责人:
    Prof Mark Febbraio
  • 依托单位:
NAFLD, NASH and Hepatocellular carcinoma: Mechanisms & Potential Treatments
  • 批准号:
    nhmrc : 1122227
  • 项目类别:
    Project Grants
  • 资助金额:
    $47.38万
  • 财政年份:
    2017
  • 负责人:
    Prof Mark Febbraio
  • 依托单位:
国内基金
海外基金
Tfh/IL-21信号轴与M2巨噬细胞交互对话在低氧性肺动脉高压中的作用及机制研究
基于“大气下陷”理论探讨升陷汤调控IL-17A/IL-17RA信号轴抑制MMP-2/MMP-9表达抗心衰大鼠心肌纤维化的作用机制
  • 批准号:
    2026JJ80502
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    王雪
  • 依托单位:
儿童腺样体肥大中肠道菌群-免疫轴通过GPR43对IL-17A的调控作用
草鱼NF-κB p50与IL-10启动子的结合特性及其调控效应