Mapping and defining inter-organ cross talk during exercise

该项目旨在精确研究器官如何交流和相互作用。这些相互作用在运动期间尤其重要，因为持续的运动需要复杂的器官通信，并且随着年龄的增长对整个生物体产生重大影响。这种通讯究竟是如何发生的尚不清楚，但我们现在知道，货物与细胞外囊泡（EV）的运动在器官间通讯中起着不可或缺的作用。该项目预计将建立在我们在通过电动汽车进行器官间通信的生物学方面取得的前所未有的最新进展的基础上。预期成果将对生命科学和生物技术产生广泛影响。

This project aims to examine precisely how organs communicate and interact. These interactions are particularly important during exercise, when continued movement demands intricate organ communication, and have major ramifications for the whole organism as it ages. Precisely how this communication takes place is unclear, but we now know that the movement of cargo with extracellular vesicles (EVs) plays an integral role in organ to organ communication. This project expects to build upon unprecedented recent developments we have made in the biology of inter-organ communication via EVs. The expected outcomes will have broad impact across life science and biotechnology.