Effects of magnetic and electric fields, mechanical stress on the conformational state and release behavior of the composite gels with embedded colloid particles

磁场、电场、机械应力对包埋胶体颗粒复合凝胶构象状态及释放行为的影响

• 批准号: 28463128
• 负责人: Professor Dr. Alexei R. Khokhlov
• 金额: --
• 依托单位: Institut für Theoretische Chemie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/28463128?language=en
• 关键词: Effects; magnetic; electric; fields; mechanical

The aim of the project is the synthesis of novel phase separated hydrogels composed of A/-isopropylacrylamide, hydrophobic components (drugs/dyes) and nanostructured silica by a combination of advanced techniques such as (mini)emulsion polymerization, sol-gel processing, and cooperative self-assembly relying on hydrolysis and condensation reactions of molecular precursors in the presence of polymerizable hydrogel monomers and amphiphiles. Two different strategies will be followed: (a) hydrogels containing embedded narrowly distributed nanodroplets of water-insoluble organic and/or inorganic substances, and (b) hydrogels as (nano)droplets in a continuous inorganic gel phase. In addition to the synthetic aspects, the volume phase transitions of the composite gels will be studied, in addition to their elasticity combined with microscopic and X-ray based investigations of the emulsion droplets in the gel phase. Absorption - release properties of the composite gels will be investigated for some typical drug compounds as well as surfactants and dyes and correlated to their structure and chemical composition.

该项目的目的是合成由N-异丙基丙烯酰胺，疏水组分（药物/染料）和纳米结构二氧化硅组成的新型相分离水凝胶，通过先进技术的组合，如（微）乳液聚合，溶胶-凝胶加工，以及依赖于可聚合水凝胶单体和两亲物存在下分子前体的水解和缩合反应的协同自组装。将遵循两种不同的策略：（a）含有嵌入的窄分布的水不溶性有机和/或无机物质的纳米液滴的水凝胶，和（B）作为连续无机凝胶相中的（纳米）液滴的水凝胶。除了合成方面，复合凝胶的体积相变将进行研究，除了它们的弹性相结合的显微镜和X射线为基础的调查的乳液液滴在凝胶相。研究了复合凝胶对一些典型药物、表面活性剂和染料的吸收-释放性能，并将其与其结构和化学组成进行了关联。