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Helical 3-D X-ray Dark-field Imaging

螺旋 3D X 射线暗场成像

基本信息

批准号：
289363653
负责人：
Professorin Dr. Gisela Anton
金额：
--
依托单位：
Lehrstuhl für Informatik 5: Mustererkennung
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2018-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/289363653?language=en
关键词：
Helical ray Dark field Imaging

项目摘要

The dark-field signal of an X-ray phase-contrast system captures the small-angle scattering of microscopic structures. It is acquired using Talbot-Lau interferometer, and a conventional X-ray source and a conventional X-ray detector. Interestingly, the measured intensity of the dark-field signal depends on the orientation of the microstructure. Using algorithms from tomographic image reconstruction, it is possible to recover these structure orientations. The size of the imaged structures can be considerably smaller than the resolution of the used X-ray detector. Hence, it is possible to investigate structural properties of - for example - bones or soft tissue at an unprecedented level of detail.Existing methods for 3-D dark-field reconstruction require sampling in all three spatial dimensions. For practical use, this procedure is infeasible.The goal of the proposed project is to develop a system and a method for 3-D reconstruction of structure orientations based on measurements from a practical imaging trajectory. To this end, we propose to use a helical trajectory, a concept that has been applied in conventional CT imaging with tremendous success. As a result, it will be possible for the first time to compute dark-field volumes from a practically feasible, continuous imaging trajectory. The trajectory does not require multiple rotations of the object or the patient and avoids unnecessarily long path lengths.The project will be conducted in cooperation between the experimental physics and the computer science department. The project is composed of six parts:- A: Development of a 3-D cone-beam scattering projection model- B: Development of reconstruction algorithms for a helical dark-field imaging system- C: Evaluation and optimization of the reconstruction methods towards clinical applications- D: Design of an experimental helical imaging system- E: Setup of the helical imaging system- F: Evaluation and optimization of the system performanceParts A to C will be performed by the computer science department. Parts D to E will be conducted by the experimental physics department.

X 射线相衬系统的暗场信号捕获微观结构的小角度散射。它是使用 Talbot-Lau 干涉仪、传统 X 射线源和传统 X 射线探测器获得的。有趣的是，暗场信号的测量强度取决于微结构的方向。使用断层扫描图像重建算法，可以恢复这些结构方向。成像结构的尺寸可能比所使用的 X 射线探测器的分辨率小得多。因此，可以以前所未有的详细程度研究骨骼或软组织等的结构特性。现有的 3D 暗场重建方法需要在所有三个空间维度进行采样。对于实际应用来说，这个过程是不可行的。所提议项目的目标是开发一种基于实际成像轨迹测量的结构方向 3D 重建的系统和方法。为此，我们建议使用螺旋轨迹，这一概念已应用于传统 CT 成像并取得了巨大成功。因此，首次有可能从实际可行的连续成像轨迹计算暗场体积。该轨迹不需要物体或患者多次旋转，并避免不必要的长路径长度。该项目将由实验物理和计算机科学系合作进行。该项目由六个部分组成：- A：3D锥束散射投影模型的开发- B：螺旋暗场成像系统重建算法的开发- C：针对临床应用的重建方法的评估和优化- D：实验螺旋成像系统的设计- E：螺旋成像系统的设置- F：系统性能的评估和优化将执行A至C部分由计算机科学系。 D 至 E 部分将由实验物理系进行。