Modulation of hepatic and systemic manifestations of chronic liver disease by the signaling molecule Reelin (B10)

点击翻译按钮获取中文摘要

Based on our previous work the project investigates the role of hepatically derived Reelin in liver regeneration and fibrosis. For this purpose, a rat model of inducible Reelin inactivation was developed. Conditional Reelin inactivation in the liver using inducible Cre promoters allows the analysis of the role of Reelin in liver regeneration, studies on the influence of Reelin in a toxic liver damage model and its effect on steatohepatitis. In particular, our hypothesis that Reelin has an important role in the maintenance of the hepatic stem cell niche will be investigated.