Modulation of hepatic and systemic manifestations of chronic liver disease by the signaling molecule Reelin (B10)

信号分子 Reelin (B10) 调节慢性肝病的肝脏和全身表现

• 批准号: 290206396
• 金额: --
• 依托单位: Klinik für Gastroenterologie, Hepatologie und Infektiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/290206396?language=en
• 关键词: Modulation; hepatic; systemic; manifestations; chronic

Based on our previous work the project investigates the role of hepatically derived Reelin in liver regeneration and fibrosis. For this purpose, a rat model of inducible Reelin inactivation was developed. Conditional Reelin inactivation in the liver using inducible Cre promoters allows the analysis of the role of Reelin in liver regeneration, studies on the influence of Reelin in a toxic liver damage model and its effect on steatohepatitis. In particular, our hypothesis that Reelin has an important role in the maintenance of the hepatic stem cell niche will be investigated.

基于我们以前的工作，该项目研究了肝源性Reelin在肝再生和纤维化中的作用。为此，开发了诱导性Reelin失活的大鼠模型。使用诱导型Cre启动子在肝脏中有条件的Reelin失活允许分析Reelin在肝再生中的作用，研究Reelin在毒性肝损伤模型中的影响及其对脂肪性肝炎的影响。特别是，我们的假设，即Reelin在维持肝干细胞龛中具有重要作用，将进行研究。