Psychobiological stress regulation and aggression: Investigations on the dimensionality of externalization

心理生物学压力调节和攻击性：外化维度的研究

• 批准号: 299375468
• 负责人: Professorin Dr. Brigitte M. Kudielka
• 金额: --
• 依托单位: Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/299375468?language=en
• 关键词: Psychobiological; stress; regulation; aggression; Investigations

The externalizing spectrum is characterized by disinhibition/impulsivity, antisocial-aggressive behavior as well as substance use and misuse. The major aim of the proposed project is to investigate the thesis that interindividual differences in externalizing behavior are associated with neuronal, emotional, cognitive and psychoendocrine stress regulation. We also postulate that differences in the extent of externalizing behavior predict aggressive behavior rates after acute stress exposure and that externalizing behavior is related to differential neuronal activation patterns during aggression induction. Although externalizing is characterized by altered emotional reactivity, to date, there is a lack of data on psychological and psychobiological stress regulation. Externalizing is not a categorical but a continuous construct. Thus, externalizing behavior will be investigated across a wide range of normal variation in a homogenous and well-characterized sample of normal and healthy adults. This approach allows to minimize otherwise typical confounding factors like comorbidity (e.g., in psychiatric and forensic samples) or significant contextual conditions (e.g., incarceration). To evaluate if our findings in subjects from the general population can be generalized to clinical samples, we additionally examine a forensic sample of men characterized by an early-acquired and persistent pattern of antisocial-aggressive behavior. As biological outcome measures, we propose assessing endocrine parameters (cortisol, testosterone); as psychological variables, we plan measuring emotional and cognitive responses to acute stress exposition. We expect dissociations between endocrine stress responses on the one hand and emotional and cognitive stress responses on the other. Applying an experimental design (acute stress induction versus control condition) we also investigate behavioral effects in a standardized acute aggression-induction-paradigm. We expect a higher rate of aggressive behavior after aggression-induction in subjects with a higher degree of externalization (in particular in subjects with forensic background) as well as associations between indices of aggressive behavior and emotional and endocrine responses to stress. A further important aim of the present project is the investigation of neuronal activation patterns during acute stress as well as aggression induction during functional magnetic resonance imaging (fMRI). We expect that the individual degree of externalization is associated with specific neuronal response patterns in, for example, the amygdala, cingulate cortex and prefrontal cortex.

外化光谱的特征是去抑制/冲动、反社会攻击行为以及物质使用和滥用。该项目的主要目的是研究外化行为的个体间差异与神经元、情绪、认知和心理内分泌应激调节有关的这一命题。我们还假设，外化行为程度的不同可以预测急性应激暴露后的攻击行为发生率，外化行为与攻击诱导过程中不同的神经元激活模式有关。尽管外化的特征是情绪反应的改变，但到目前为止，关于心理和心理生物压力调节的数据还很缺乏。外化不是一个直截了当的概念，而是一个连续不断的结构。因此，外化行为将在正常和健康成年人的同质和特征良好的样本中进行广泛的正常变化范围的调查。这一方法可以最大限度地减少其他典型的混杂因素，如共病(例如，在精神病和法医样本中)或重要的背景条件(例如，监禁)。为了评估我们在普通人群受试者中的发现是否可以推广到临床样本，我们另外检查了具有早期获得的和持续的反社会攻击行为模式的男性的法医样本。作为生物学结果的衡量标准，我们建议评估内分泌参数(皮质醇、睾酮)；作为心理变量，我们计划衡量情绪和认知对急性压力暴露的反应。我们预计内分泌应激反应与情绪和认知应激反应之间存在分离。应用实验设计(急性应激诱导与控制条件)，我们还研究了标准化急性攻击诱导范式中的行为效应。我们预计，外化程度越高的受试者(特别是具有法医背景的受试者)在攻击诱导后的攻击性行为比率更高，并且攻击性行为指数与对压力的情绪和内分泌反应之间存在关联。本项目的另一个重要目标是研究功能磁共振成像(FMRI)中急性应激和攻击诱导过程中神经元的激活模式。我们预计，个体的外化程度与特定的神经元反应模式有关，例如，杏仁核、扣带皮质和前额叶皮质。

项目成果

Exploring the differential contribution of boldness, meanness, and disinhibition to explain externalising and internalising behaviours across genders

• DOI: 10.1007/s12144-021-02134-3
• 发表时间: 2021-07-28
• 期刊: CURRENT PSYCHOLOGY
• 影响因子: 2.8
• 作者: Eisenbarth, Hedwig;Hart, Claire M.;Wuest, Stefan
• 通讯作者: Wuest, Stefan

Validation of a monetary Taylor Aggression Paradigm: Associations with trait aggression and role of provocation sequence

货币泰勒攻击范式的验证：与特征攻击和挑衅序列的作用的关联

• DOI: 10.1016/j.jesp.2020.103960
• 发表时间: 2020
• 期刊: Journal of Experimental Social Psychology
• 影响因子: 3.5
• 作者: Konzok J;Kreuzpointner L;Henze G.I;Wagels L;Kärgel C;Weidacker K;Schiffer B;Eisenbarth H;Wüst S. ;Kudielka B.M.
• 通讯作者: Kudielka B.M.