Psychobiological investigation of the socioemotional functioning in autism

自闭症社会情绪功能的心理生物学调查

• 批准号: 8264378
• 负责人: Blythe Anne Corbett
• 金额: $ 34.75万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264378
• 关键词: Accounting; Affect; Amygdaloid structure; Arousal; Autistic Disorder; Behavior; Behavior Therapy; Behavioral; Biological; Biological Markers; Brain; Brain region; Child; Child Behavior; Code; Cognitive deficits; Computers; Data; Defect; Disease; Emotional; Emotional Disturbance; Equipment; Exhibits; Exposure to; Frequencies; Functional Magnetic Resonance Imaging; Goals; Heterogeneity; Home environment; Hormones; Human; Hydrocortisone; Hypothalamic structure; Imaging Techniques; Individual; Investigation; Language Disorders; Measurement; Measures; Methods; Modeling; Neurobiology; Neurosecretory Systems; Participant; Pattern; Performance; Periodicity; Physiological; Pituitary Gland; Play; Process; Regulation; Rewards; Salivary; Sampling; Social Behavior; Social Interaction; Social Problems; Stress; Symptoms; Techniques; Toy; Variant; base; behavior observation; falls; frontal lobe; indexing; neuroimaging; novel; peer; preference; psychobiologic; psychobiology; public health relevance; relating to nervous system; response; social

DESCRIPTION (provided by applicant): Autism is currently widely viewed as a spectrum disorder with affected individuals having varying degrees of social and emotional disturbances. In the present application we describe a new conceptualization of autism in order to account for some of the heterogeneity. In the application, a neuroendocrine spectrum model is proposed in which aspects of emotional reactivity, social responsiveness and biological indices intersect to define distinct subtypes. The investigation involves three interrelated studies of socioemotional functioning utilizing several methods of analysis to include the assessment of biological markers of emotional arousal and stress, sophisticated behavioral observational techniques, and functional neuroimaging in order to carefully explore the psychobiological profiles of children with and without autism. Specifically, during peer interactions of a playground activity, sophisticated behavioral observation will be obtained to evaluate the frequency, duration and interactive sequences exhibited by children with autism. These data will be analyzed with stress hormones to uncover relationships between behavioral and biological symptom profiles. In addition, we will explore brain activation patterns in these children while they play games with different computer and human partners. It is anticipated that this comprehensive study of "real world" social interactions will allow us to uncover meaningful associations between the child's behavior, biological profiles and brain activity before, during and after play with peers. The ultimate goal is that these results will better inform our understanding of autism to allow us to provide individualized biological and behavioral treatments. PUBLIC HEALTH RELEVANCE: Autism is a spectrum disorder in which affected individuals have varying degrees of social and emotional disturbances. In the application, a model is proposed in which aspects of emotional reactivity, social responsiveness and biological measures are combined to form distinct subtypes. Social and emotional functioning of children with autism is explored using sophisticated behavioral observations of social interactions, measurement of stress hormones, and the study of brain activity in response to playing games during "real world" interactions to help us to better understand the variability of behavior, brain and hormones in children with autism.

描述（由申请人提供）：自闭症目前被广泛视为一种谱系障碍，受影响的个体具有不同程度的社交和情感障碍。在本申请中，我们描述了自闭症的新概念，以解释一些异质性。在该申请中，提出了一种神经内分泌谱模型，其中情绪反应性、社会反应性和生物指数等方面交叉以定义不同的亚型。该调查涉及社会情绪功能的三项相互关联的研究，利用多种分析方法，包括评估情绪唤起和压力的生物标记、复杂的行为观察技术和功能神经影像，以便仔细探索患有和没有自闭症儿童的心理生物学特征。具体来说，在游乐场活动的同伴互动过程中，将获得复杂的行为观察，以评估自闭症儿童表现出的频率、持续时间和互动顺序。这些数据将通过压力荷尔蒙进行分析，以揭示行为和生物症状之间的关系。此外，我们将探索这些孩子与不同的计算机和人类伙伴玩游戏时的大脑激活模式。预计这项对“现实世界”社交互动的全面研究将使我们能够揭示孩子在与同伴玩耍之前、期间和之后的行为、生物特征和大脑活动之间的有意义的关联。最终目标是这些结果将更好地帮助我们了解自闭症，使我们能够提供个性化的生物和行为治疗。 公共卫生相关性：自闭症是一种谱系障碍，受影响的个体有不同程度的社交和情感障碍。在该应用中，提出了一个模型，其中情绪反应性、社会反应性和生物测量的各个方面被结合起来形成不同的亚型。通过对社交互动的复杂行为观察、应激激素的测量以及对“现实世界”互动中玩游戏的大脑活动的研究，探索自闭症儿童的社交和情感功能，以帮助我们更好地了解自闭症儿童的行为、大脑和激素的变异性。