Online assessment of the crystalline modification of nanoparticles in the gas phase

纳米粒子在气相中的结晶改性的在线评估

• 批准号: 310472725
• 负责人: Professor Dr.-Ing. Andreas Bräuer
• 金额: --
• 依托单位: Institut für Thermische Verfahrenstechnik, Umwelt- und Naturstoffverfahrenstechnik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/310472725?language=en
• 关键词: Online; assessment; crystalline; modification; nanoparticles

The synthesis of nanoparticles from the gas phase is resource-efficient and common. Thanks to cause and effect studies, it is known that particle properties (size, morphology, degree of agglomeration, crystallinity) can be changed by a variation of process parameters. Presently, the properties of the synthesized particles are characterized offline with considerable time delay after sample extraction and preparation, thus yielding only scarce information about the process-to-product event chain and not allowing direct influence on it. Within the second funding phase of the DFG/AIF joint project - Multi parameter characterization of particle based functional materials by means of innovative online measurement systems (MPaC) - , hereby an online and in-situ method of measurement for the analysis of the CRYSTALLINITY of particles in the gas phase is to be developed and tested in a new sub-project. The crystallinity as an internal structural parameter of particles has enormous relevance for the means of application, such as the bioavailability of active agents or the conductivity of particles. With this project, the hitherto not covered aspect of the parameter CRYSTALLINITY complements the works for the analysis of morphology, size and structure of the other MPaC sub-projects. Aim of this project is the development of a new Raman measurement process for the online and in-situ assessment of the crystalline modification of nanoparticles in the gas phase, with the simultaneous analysis of the gas phase temperature and composition. This allows investigating into the influence of varied process parameters on the resulting product properties in corresponding gas phase particle processes. By means of Raman spectroscopy, it is possible to distinguish polymorphs in aerosols by their characteristic spectral signatures. Simultaneously the gas phase temperature is ascertained from the rotational Raman spectrum of nitrogen. Due to the relatively weak cross-section of Raman scattering compared to concurring light-matter interactions, particular attention is paid to the efficient excitation and detection of the Raman signals, at the same time minimizing concurring and interfering disturbing signals (chemiluminescence, fluorescence). This will be realized by optimizing and building up a custom-made spectrometer especially for this project, and the application of the Shifted Excitation Raman Difference Spectroscopy (SERDS) method. The measurement method will be developed on the basis of the particle systems Titanium dioxide, Zirconium dioxide, and Iron(III) oxide dispersed in the gas phase.

来自气相的纳米颗粒的合成是资源效率和常见的。由于原因和效果研究，众所周知，粒子特性（大小，形态，聚集程度，结晶度）可以通过过程参数的变化来改变。目前，在样品提取和制备后，综合颗粒的特性在离线延迟时被大量延迟表征，因此仅产生有关产品到产品之间事件链的稀缺信息，而不允许直接影响它。在DFG/AIF关节项目的第二个融资阶段 - 通过创新的在线测量系统（MPAC）对基于粒子的功能材料的多参数表征，此处是一种在线和原位测量方法，用于分析气相中颗粒的结晶度的分析，并在新的子喷射中开发并测试。作为颗粒的内部结构参数的结晶度与应用程序的含量具有巨大的相关性，例如活性剂的生物利用度或颗粒的电导率。在这个项目中，迄今未涵盖参数结晶度的各个方面可以补充其他MPAC子项目的形态，大小和结构的作品。该项目的目的是开发新的拉曼测量过程，用于在线和原位评估气相中纳米颗粒的结晶修饰，并同时分析气相温度和组成。这允许研究各种过程参数对相应气相颗粒过程所得产物性能的影响。通过拉曼光谱法，可以通过其特征光谱特征区分气溶胶中的多晶型物。同时，从氮的旋转拉曼光谱中确定了气相温度。由于拉曼散射的横截面相对较弱，与同意的光 - 物质相互作用相比，特别注意拉曼信号的有效激发和检测，同时最大程度地减少了同意和干扰干扰信号（化学发光（化学发光，荧光））。这将通过优化和构建定制的光谱仪，特别是对于该项目来实现，以及移动的激发拉曼差异光谱（SERDS）方法的应用。该测量方法将根据二氧化钛，二氧化锆和铁（III）氧化物的颗粒系统钛的基础开发。