敗血症臓器障害におけるVEGFとアンジオポエチンの研究：短期型βブロッカーの作用

VEGF 和血管生成素在脓毒症器官损伤中的研究：短效 β 受体阻滞剂的作用

• 批准号: 20K09282
• 负责人: 河野 了
• 金额: $ 2.83万
• 依托单位: Ibaraki Prefectural University of Health Science (2021-2022)University of Tsukuba (2020)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K09282/
• 关键词: VEGF; アンジオポエチン; ランジオロール

We completed 3 years of this research. With working on acute lung injury, we also did many experiments on LPS-induced myocardial dysfunction and liver injury. Morphologically, landiolol hydrochloride, an ultra-short-acting β-blocker, plays vital role in lessening LPS-induced cardiac and liver injury. We used male Wistar rats at 8 weeks of age and were administered with either saline or lipopolysaccharide (LPS) for three hours (3h), and some of the LPS-administered rats were continuously treated with landiolol for 3h, extending experiments for 6h and 10h. We have seen the changes in both circulatory and tissue TNF-α and IL-6 with alteration of level of angiopoietin-2 in heart and liver. These changes were accompanied an LPS-induced considerable alteration in cardiac and liver levels of VEGF with Pa02. Here we found that the treatment of LPS-administered rats with landiolol starting from 3h significantly stopped the progression of cardiac dysfunction and liver injury with marked normalization of angiopoietin-2. This treatment also considerably normalized blood gas parameters, and tissue VEGF levels. Collectively, our data indicate that landiolol treatment in LPS-administered rats plays an essential role in attenuating cardiac dysfunction and liver injury through modulation of angiopoietin-2 with concomitant VEGF signaling reversal.

我们完成了3年的研究。在研究急性肺损伤的同时，我们还做了大量lps诱导心肌功能障碍和肝损伤的实验。从形态学上看，盐酸兰地洛尔是一种超短效β受体阻滞剂，在减轻lps诱导的心脏和肝脏损伤中起重要作用。我们选用8周龄雄性Wistar大鼠，分别给予生理盐水或脂多糖（LPS） 3小时（3h），部分脂多糖大鼠连续给予兰地洛尔3h，延长实验时间为6h和10h。我们观察到循环和组织中TNF-α和IL-6的变化以及心脏和肝脏中血管生成素-2水平的改变。这些变化伴随着lps诱导的Pa02在心脏和肝脏VEGF水平的显著改变。本研究发现，从lps给药的大鼠3h开始服用兰地洛尔，可以显著阻止心功能障碍和肝损伤的进展，血管生成素-2明显正常化。这种治疗也显著地使血气参数和组织VEGF水平正常化。总的来说，我们的数据表明，在lps给药的大鼠中，兰地洛尔治疗通过调节血管生成素-2并伴随VEGF信号逆转，在减轻心功能障碍和肝损伤方面发挥了重要作用。

项目成果

A Brief Look at Omicron Condition in Bangladesh: Dealing with another variant.

孟加拉国 Omicron 状况简述：应对另一种变体。

• 发表时间: 2022
• 期刊: Journal of Medical - Clinical Research & Reviews
• 作者: Jesmin;S.; Matsuishi;Y.; Sohael;F.; Imtiaz;A.; Shimojo;N.; Shima;T.; Yamaguchi;N.; Rahman;A.; Maqbool;A.; Kawano;S.,Moroi;M.
• 通讯作者: M.

Daily walking habit reduces fasting blood sugar level in newly diagnosed diabetic participants in rural Bangladesh

每日步行习惯可降低孟加拉国农村新诊断糖尿病参与者的空腹血糖水平

• DOI: 10.7600/jpfsm.10.85
• 发表时间: 2021
• 期刊: The Journal of Physical Fitness and Sports Medicine
• 作者: Jesmin Subrina;Shima Takeru;Yamaguchi Naoto;Sohael Farzana;Maqbool Adil;Rahman Arifur;Moroi Masao;Shimojo Nobutake;Kawano Saturo;Watanabe Koichi;Takeda Fumi;Soya Hideaki
• 通讯作者: Soya Hideaki

Community survey, knowledge and attitude of Bangladeshi people during the time of Omicron Variant emergence

Omicron 变种出现期间孟加拉国人民的社区调查、知识和态度

• 发表时间: 2022
• 期刊: International J Biomed Res Prac
• 作者: Jesmin;S.; Maqbool;A.; Rahman;M.A.; Sohael;F.; Matsuishi;Y.; Shima;T.; Shimojo;N.; Kawano;S.; Yamaguchi;N.; Moroi;M
• 通讯作者: M

Monkeypox and an Interesting Look at Changes in Epidemiology

猴痘和流行病学变化的有趣观察

• DOI: 10.37871/jbres1528
• 发表时间: 2022
• 期刊: Journal of Biomedical Research & Environmental Sciences
• 作者: Jesmin Subrina;Rahman Md. Arifur;Sohael Farzana;Shimojo Nobutake;Yamaguchi Naoto;Kawano Satoru;Moroi Masao
• 通讯作者: Moroi Masao

Covid-19 Vaccination status in Bogura district in Bangladesh.

孟加拉国博古拉地区的 Covid-19 疫苗接种情况。

• 发表时间: 2022
• 期刊: Journal of Biomedical Research & Environmental Sciences
• 作者: Jesmin;S.; Maqbool;A.; Sohael;F.; Islam;M.M.; Matsuishi;Y.; Shima;T.; Shimojo;N.; Kawano;S.; Rahman;M.A.; Yamaguchi;N.; Moroi;M.
• 通讯作者: M.