Feeding regulation in jellyfish

水母的摄食调节

• 批准号: 20K15838
• 负责人: Thoma Vladimiros
• 金额: $ 2.66万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K15838/
• 关键词: Jellyfish; Appetite; Evolution; Feeding; Neuropeptide; Cnidarian; Drosophila; Neurobiology; Bahaviour

The main research achievement has been the publication of a research article entitled ‘On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide’ in the international journal PNAS. This required additional experiments and analyses, as requested by the reviewers, including: (a) further characterization of the behavioral effects of GLWamide; (b) anatomical characterization of peptide-expressing neurons in Drosophila and Cladonema and (c) bioinformatic analysis of Cladonema G protein-coupled receptors. Following publication, I also built on the results by characterizing the effect of satiety in the jellyfish Cladonema in greater detail.

主要的研究成果是在国际期刊PNAS上发表了一篇题为“关于食欲的起源：水母中的GLWamide代表了祖先的饱腹神经肽”的研究文章。这需要根据审稿人的要求进行额外的实验和分析，包括：(a)进一步表征GLWamide的行为效应；(b)果蝇和枝线虫多肽表达神经元的解剖特征和(c)枝线虫G蛋白偶联受体的生物信息学分析。在论文发表之后，我还在研究结果的基础上，更详细地描述了饱腹感对水母Cladonema的影响。