Integrating behavior, hormones and genes associated with the primate HPA-axis

整合与灵长类 HPA 轴相关的行为、激素和基因

• 批准号: 315725133
• 负责人: Professorin Dr. Julia Ostner
• 金额: --
• 依托单位: Hormonlabor
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/315725133?language=en
• 关键词: Integrating; behavior; hormones; genes; associated

In social species stressful interactions are pervasive and thus mounting an adequate behavioral and physiological stress response is crucial for an individual to maintain internal homeostasis. The central signaling pathway activated in response to stress in vertebrates is the HPA-axis. While experimental studies on humans started to link variation in genes associated with the HPA-axis to individual stress responsiveness, genetic influences on individual stress reactivity have been largely neglected in non-human primates. The few studies conducted on nonhuman primates also used experimental setups and mostly focussed on single candidate genes, rather than screening several gene loci related to HPA-axis functioning. In this project using non-invasive methods we will investigate how genetic predispositions shape the behavioral and endocrine response to naturally occurring stressors in individually known wild Assamese macaques (Macaca assamensis) living in their natural habitat in Thailand. First, we will determine the variation in HPA-related genes by genotyping 50 polymorphisms in 19 genes involved in HPA-axis activity. Second, we will combine detailed behavioral data from individual adult males from four social groups with individual HPA-related genetic setup to link gene variants to behavioral styles. Third, we will link HPA-related gene variants to physiological stress-responsiveness towards naturally occurring social and environmental stressors in adult males. Together, these data will contribute to a more comprehensive understanding of the factors shaping stress responsiveness in primates including humans.

在社会物种中，压力相互作用是普遍存在的，因此建立适当的行为和生理压力反应对个体维持内部稳态至关重要。在脊椎动物中，响应于应激而激活的中央信号传导途径是HPA轴。虽然对人类的实验研究开始将与HPA轴相关的基因变异与个体应激反应联系起来，但在非人类灵长类动物中，遗传对个体应激反应的影响在很大程度上被忽视了。在非人类灵长类动物中进行的少数研究也使用了实验装置，并且大多集中在单个候选基因上，而不是筛选与HPA轴功能相关的几个基因位点。在这个项目中，使用非侵入性的方法，我们将调查遗传倾向如何塑造行为和内分泌反应自然发生的压力在个别已知的野生阿萨姆猕猴（Macaca assamensis）生活在他们的自然栖息地在泰国。首先，我们将通过对涉及HPA轴活性的19个基因中的50个多态性进行基因分型来确定HPA相关基因的变异。其次，我们将联合收割机将来自四个社会群体的成年男性个体的详细行为数据与个体HPA相关的遗传设置结合起来，将基因变异与行为方式联系起来。第三，我们将连接HPA相关的基因变异生理压力反应自然发生的社会和环境压力在成年男性。总之，这些数据将有助于更全面地了解包括人类在内的灵长类动物的压力反应因素。