Understanding the role of caspase-2 in cellular stress response and ageing

了解 caspase-2 在细胞应激反应和衰老中的作用

• 批准号: nhmrc : 1021456
• 负责人: Prof Sharad Kumar
• 金额: $ 61.25万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-caspase-response-ageing/110123
• 关键词: Understanding; role; caspase; cellular; stress

This project builds upon our recent findings showing that a protein, called caspase-2, is involved in protecting against oxidative damage and ageing in a mouse model. We propose to carry out further studies to fully understand how caspase-2 regulates cell’s response to oxidative stress. Such studies will be critical in assessing if caspase-2 or its substrates are useful targets for drugs to treat diseases that may arise due to cell’s inability to properly respond to oxidative damage.

该项目建立在我们最近的发现基础上，该发现表明一种名为caspase-2的蛋白质参与保护小鼠模型免受氧化损伤和衰老。我们建议进行进一步的研究，以充分了解caspase-2如何调节细胞对氧化应激的反应。这些研究对于评估胱天蛋白酶-2或其底物是否是药物治疗疾病的有用靶点至关重要，这些疾病可能是由于细胞无法正确应对氧化损伤而引起的。